Method and system for analysing sound

ABSTRACT

The present invention relates to a method and system for analysing audio (eg. music) tracks. A predictive model of the neuro-physiological functioning and response to sounds by one or more of the human lower cortical, limbic and subcortical regions in the brain is described. Sounds are analysed so that appropriate sounds can be selected and played to a listener in order to stimulate and/or manipulate neuro-physiological arousal in that listener. The method and system are particularly applicable to applications harnessing a biofeedback resource.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. application Ser. No.15/676,042, filed Aug. 14, 2017, which is a continuation of U.S.application Ser. No. 14/125,107, filed Jun. 27, 2014, which claims thepriority of PCT/GB2012/051314, filed on Jun. 11, 2012, which claimspriority to Great Britain Application No. 1109731.8, filed Jun. 10,2011, the entire contents of each of which is fully incorporated hereinby reference.

BACKGROUND OF THE INVENTION 1. Field of the Invention

The present invention relates to a method and system for analysing sound(e.g.

music tracks). Tracks from a database of sounds, for example music, canbe analysed in order to predict automatically the effect or impact thosesounds will have on a listener.

2. Technical Background

It is well established that there are specific levels ofneuro-physiological arousal (related to mood, states of mind and affect)best suited to particular activities such as study, relaxation, sleep orathletic performance. However, because these levels of arousal resultfrom complex interactions between the conscious mind, environmentalstimuli, the autonomic nervous system, endocrine activity,neurotransmission and basal metabolism, it is difficult to control andsustain them.

It is also well established that there is a universal human response tomusic based on a complex set of functions ranging from perceptualsystems, by way of cerebral cortex and other processing, to activationof core emotional centres of the brain and the somatic systems. It issimilarly well established that these functions reside in parts of thebrain such as, for example, the cochlea, primary auditory cortex,pre-motor cortex, amygdala and the periaqueductal grey (and so on).Rhythm, for example, has a measurable effect on the pre-motor cortex,autonomic nervous system, somatic systems, the endocrine system andneurotransmission. Other aspects of musical structure and experience mayalso influence human neurophysiology, as described below.

3. Discussion of Related Art

Three ways are known of analysing music for arousal and counter-arousalusing humans (for brevity, the term ‘arousal’ will at times be used toinclude counter-arousal in this document). The first method entails thejudgment of an individual, who might be either an expert or the subjecthim or herself. The second method is by testing many people and askingthem how they feel in response to different music tracks. Neither isreliable because each is too subjective.

The third method is to analyse metrics computed as a function of themusic itself (usually tempo, but may also include a measure of averageenergy), and relate such metrics to the desired state of arousal of thesubject. There are several such systems, some of which are cited below.Most rely on either ‘entrainment’ (in the Huygens sense, namely thetendency to synchronise to an external beat or rhythm) or on theassociation of increased tempo (and in one known case, energy) withincreased effort or arousal (and the converse for reduced tempo andenergy).

Examples of prior art systems that use music selected according to tempoto manipulate arousal and counter-arousal include US 282045, US191037,US113725, US 270667, WO 151116, U.S. Pat. No. 5,267,942). This art mayuse beats per minute as calculated to predict entrainment or may, as inUS 060446, modulate tempo in order to improve entrainment. Although thisart may be directionally correct, and by extension of Huygens'entrainment principle, it is likely to work to some extent with somerepertoire, tempo is both difficult to detect automatically and on itsown may best be used to calculate neuro-physiological effect in thelimited circumstances where the tempo is both easily and accuratelydetected and where it is close to the current heart rate of the listener(see next paragraph). Any significant divergence and the entrainmenteffect is likely to be lost. Most significantly, as discussed below,effective rhythmic entrainment depends on more than beats per minute,and is inseparably synergetic with and dependent on other musicalgenerators of arousal, such as, for example harmonicity and turbulence.

U.S. Pat. No. 5,667,470 relies on the fulfilment or denial of expectedoutcomes in music in comparison with established patterns in therepertoire, while U.S. Pat. No. 4,883,067 introduces the concept oftraining the brain to replicate positive patterns of neurologicalactivity by association with certain sound signals. One patent, U.S.Pat. No. 5,267,942, cites the iso-moodic principle documented byAltshuler in 1948 as evidence for its assertion that for the tempo ofmusic to have any effect in entraining heart rate it must lie within the‘entrainment range’ of the individual's actual heart rate, i.e. close toit. This introduces the notion that the neuro-physiological effect of apiece of music depends on the initial state of the subject, which meansthat the effect of any given piece of music is relative rather thanabsolute. Reference may also be made to US 2007/0270667 attempts to usebiometric feedback to manipulate arousal.

Reference may also be made to psychoacoustics. Psychoacoustics has beenextensively used in music compression technology (e.g. MP3), but anotherapplication is documented in U.S. Pat. No. 7,081,579, which describes anapproach to song similarity analysis based on seven measuredcharacteristics: brightness, bandwidth, volume, tempo, rhythm, lowfrequency noise and octave. These techniques can identify ‘soundalike’music (of which there is much these days) but cannot be used to predictthe effect of music in neuro-physiological terms.

SUMMARY OF THE INVENTION

The invention is a computer implemented system for analysing sounds,such as audio tracks, the system automatically analysing soundsaccording to musical parameters derived from or associated with apredictive model of the neuro-physiological functioning and response tosounds by one or more of the human lower cortical, limbic andsubcortical regions in the brain;

and in which the system analyses sounds so that appropriate sounds canbe selected and played to a listener in order to stimulate and/ormanipulate neuro-physiological arousal in that listener.

The model is a ‘predictive model of human neuro-physiologicalfunctioning and response’ because it predicts how the brain (e.g.structures in the lower cortical, limbic and subcortical regions,including the related autonomic nervous system, endocrine systems, andneuro-transmission systems), will respond to specific sounds.

In one implementation, tracks from a database of music are analysed inorder to predict automatically the neuro-physiological effect or impactthose sounds will have on a listener. Different audio tracks and theiroptimal playing order can then be selected to manipulateneuro-physiological arousal, state of mind and/or affect—for example tomove towards, to reach or to maintain a desired state of arousal orcounter-arousal, state of mind or affect (the term ‘affect’ is used inthe psychological sense of an emotion, mood or state).

We can contrast this system with conventional psychoacoustics(underlying for example MPEG MP3 audio compression algorithms) becausepsychoacoustics in general deals with how incoming pressure waves areprocessed by modelling the signal processing undertaken by, for example,the cochlea and primary auditory cortex, whereas the present inventiondeals with the effect of sound—e.g. the neuro-physiological functioningand response to sound in the lower cortical, limbic and subcorticalregions of the brain. Also, the science of psychoacoustics is notconcerned with selecting specific sounds for the purpose of stimulatingand manipulating desired states of arousal in a listener.

We can also contrast this system with a trivial model of musical effect,such as increased tempo leads to greater arousal. Missing entirely fromsuch model is a generalised understanding of neuro-physiologicalfunctioning and response to sound; furthermore, in practice, such amodel is so weak as to have no genuine predictive property and, for thereasons given above, is not a general solution to the technical problemof selecting different sounds so as to stimulate and manipulate arousallevels in a listener, unlike the present invention.

The musical parameters derived from or associated with the predictivemodel may relate to rhythmicity, and harmonicity and may also relate toturbulence—terms that will be explained in detail below. The inventionmay be used for the search, selection, ordering (i.e. sequencing), use,promotion, purchase and sale of music. It may further be used to select,modify, order or design non-musical sounds to have a desiredneuro-physiological effect in the listener, or to permit selection, forexample in designing or modifying engine exhaust notes, filmsoundtracks, industrial noise and other audio sources.

The invention is implemented in a system called X-System. X-Systemincludes a database of music tracks that have been analysed according tomusical parameters derived from or associated with a predictive model ofhuman neuro-physiological functioning and response to those audiotracks. X-System may include also a sensor, a musical selectionalgorithms/playlist calculator for selecting suitable tracks and aconnection to a music player. Once the sensor is activated, the systemdiagnoses the subject's initial level of neuro-physiological arousal andautomatically constructs a playlist derived from a search of an X-Systemencoded musical or sound database that will first correspond to ormirror this level of arousal, then lead the listener towards, and helpto maintain her/him at, the desired level of arousal. The playlist isrecalculated as necessary based on periodic measurements ofneuro-physiological or other indicative signals.

Measurement of neuro-physiological state may be done using a variety oftechniques, such as electro-encephalography, positron emissiontomography, plasma, saliva or other cell sampling, galvanic skinconductance, heart rate and many others, while prediction of responsemay be achieved via any suitable set of algorithms that are firsthypothesised and then refined through testing. Any given set ofalgorithms will be dependent on the stimulus being modelled and thebiometric by which the effect of the stimulus is to be measured, but,even given constant parameters, there are a number of valid mathematicalapproaches: the specific algorithms we describe in this specificationthemselves are therefore not the most fundamental feature of theinvention, even though most algorithms in the system are unique inconception and implementation. Nor are the particular biometrics chosento measure neuro-physiological state, though galvanic skin conductanceand heart rate are both suitable for general use because they enablemeasurements to be taken easily and non-invasively, while both give agood indication of arousal or counter-arousal in the autonomic nervoussystem, which is in turn largely synergetic with endocrine activity andrelated neurotransmission.

X-System represents an improvement upon existing art in that it: a)describes the bio-active components of music (beyond tempo and energy)by reference to the brain's processing of audio stimuli, includingmusic, and b) describes how any given sound source may be calibrated tothe initial state of the subject in order to have the maximumentrainment effect. It offers the advantage over many other systems thatit requires neither the modulation of tempo (tempo modulation is knownfrom US 2007/0113725, US 2007 0060446 A1, US 2006/0107822 A1) nor thecomposition of psycho-acoustically correct, synthetic music (known fromU.S. Pat. No. 4,883,067) to achieve its effect. X-System offers thepossibility of harnessing the entire world repertoire of music to themodulation of affect without needing to manipulate the rendering of themusic in any way.

X-System is based on a paradigm we shall refer to as the ‘InnateNeuro-physiological Response to Music’ (INRM—we will describe this inmore detail below), and a unique informatic modelling of one or more oflower cortical, limbic and subcortical functions related to theseresponses. X-System has a unique capacity to analyse music tracksautomatically and establish the potential to generate levels of arousaland counter-arousal in the listener. This unique method of analysis is ahuman universal and may be applied to music of all human cultures aswell as to environmental and other sound sources. X-System is capable ofcategorising databases of music and sound according to core emotionaleffect. X-System may implement automatic categorisation remotely, forexample for personal repertoires. X-System may also have the capacity todetect the state of mind and body of the user, using a unique radioelectrode and microphone based conductance/heart rate sensor and otherdevices. X-System may use this sensor data to sub-select music from anychosen repertoire, either by individual track or entrained sequences,that when listened to, will help the user to achieve a target state ofexcitement, relaxation, concentration, alertness, heightened potentialfor physical activity etc. This is achieved by analysing music tracks inthe user's database of music (using the musical parameters derived fromthe predictive model of human neuro-physiological response) and thenautomatically constructing a playlist of music, which may also bedynamically recalculated based on real-time bio-feedback, to be playedto the user in order to lead her/him towards, and help to maintainher/him at, the desired target state.

As noted above, X-System models the effect of music on specific parts ofthe lower and middle brain, including the limbic system and subcorticalsystems, but these are not the only parts of the brain that respond tomusic. Other centres govern a more personal experience involvingpreference, culture, memory and association, the meaning of the lyrics,the historical context in which they were written, the knowledge of thecircumstances of the performer or composer and other factors. These toohave a significant effect, so it is important not to expect any piece ofmusic to have an absolute effect on any one individual. INRM describesan important part of, but not all, musical effect. A prediction thatcertain pieces of music will calm the listener, or even induce sleep, isnot like a drug or an anaesthetic, where the effect of a certain dosecan be predicted with reasonable accuracy and where that effect cannotbe resisted by conscious effort. Nevertheless, tests confirm that eachof the elements of the brain that the INRM model is based on arestrongly linked to arousal and counter-arousal. Music though, has itsgreatest effect when selected appropriately to accompany a desired stateor activity and X-System offers an automated means of selecting musicthat is always appropriate to what the listener is doing, which can bevery effective in a host of situations from treating anxiety toenhancing relaxation or concentration, or stimulating creative ‘flow’,or in bringing power and fluency to athletic activity. The brainmodelling that underpins X-System offers a further capacity offered byno other existing categorisation system: it is universal; X-System mayaccurately predict levels of physiological arousal for all music of theworld repertoire, whether it be Western classical and pop, Chinese orIndian classical or folk music, African pop or roots, or avant-gardeelectronica or jazz.

X-System has proven to be capable of outperforming expert musicologistsin predicting, over a broad repertoire, a general index ofarousal/counter-arousal based on the biometric parameters of heart rateand galvanic skin resistance, but were these biometric parameters to bedifferent the equations, which we will describe later in this document,would almost certainly need to be modified; equally, there are manymathematical techniques familiar to those skilled in the art that couldhave been used to predict the neuro-physiological effect of a piece ofmusic and any one of many might produce equally satisfactory results. Akey feature of this invention therefore lies in the identification ofthe patterns in music that are neurophysiologically active(‘bio-active’) and that may have a predictable effect on humanneurophysiology, including arousal and counter-arousal.

Other Aspects of the Invention

We list fifteen further aspects of the invention below, each of whichmay also be combined with any other:

1. A computer-implemented method of categorizing sound (such as anypiece of music regardless of genre or cultural origin) (e.g. accordingto musical parameters derived from a predictive model of human lowercortical, limbic and subcortical neuro-physiological functioning andresponse to the pieces of music) in such a way that it may be selected(e.g. automatically based on biometric data captured by a sensor) toentrain neuro-physiological arousal towards a target level; this mayoccur while directing the listener towards one or more among a number ofpre-assigned states of mind and/or affect, or in order to direct thelistener towards one or more among a number of pre-assigned states ofmind and/or affect.

2. Automatic categorisation of sound (such as pieces of music) in aremote database (e.g. according to musical parameters derived from apredictive model of human lower cortical, limbic and subcorticalneuro-physiological functioning and response to the pieces of music).This includes the idea that we can search/discover music that hassimilar X-System deep structures and cross match conventionalcategorisation schemes (Gracenote® etc) to X-System. As an alternativeto, or in addition to, automatic categorisation, X-System providesselection and ‘push’ for commercial or promotional purposes, or amethodology for description or detection of particular music, for allapplications, not only entrainment. An example is a computer-implementedmethod of categorizing any piece of music regardless of genre orcultural origin according to its Innate Neuro-physiological Response toMusic for the purpose of search, navigation, music discovery, retrievaland selection.

We now expand on the concept of search/discovery, in which X-Systemprovides for automated search of musical remote or local databases andof X-System encoded services. In this application, users may:

-   -   Search for music that has similar signatures to the music they        tag that they like, by pressing a ‘find more’ or ‘I like’ key on        their computer or Smartphone X-System device App. This will        cross-match X-System encoding of universal arousal information        with other individual features within an App (such as        favourites, or frequently listened to) in order to create a new        level of personalisation;    -   Search by and for patterns of listening preferences amongst        social network groups, such that by sharing my preferences and        choices and communicating them to my friends, they will see the        relationships between my emotional response to particular tracks        and comparisons with others in the network;    -   Search by musical or experiential journey, such that a        particular sequence of music can be stored, for example, on my        Smartphone and repeated when I press ‘I liked that sequence,        store it so I can play it again’;    -   Search by finding patterns and relationships between tracks        users tag as ‘I like’, such that similar combinations of say        genre, musician, activity and X-System encoded arousal data can        drive recommendations. So, for example, X-System will generate a        playlist suggestion that will combine jazz, particular Miles        Davis tracks, writing an essay, concentration and arousal        levels, if a similar combination has been tagged from an earlier        listening sequence (the tagging of activity being part of the        Smartphone App); and    -   Search on Google and other web sites for X-System encoded        information, such that, for example, music, video or other web        content is categorised and tagged, either automatically; or in        collaboration with search engine providers such that it        ‘advertises’ X-System arousal or mood states; or according to        visitors who tag web sites automatically as they view pages.

3. An automated diagnosis of the level of lower cortical, limbic andsubcortical neuro-physiological arousal of an individual and expressingit as a value in order to correspond to the musical effect of any one ofa theoretically unlimited number of pieces of music in a database.Alternatively or additionally, there may be provided a method of trialand error of self-diagnosis e.g. by song selection as described above.

4. A computer-implemented method of creating a playlist of tracksgenerated by automatically (or indeed manually) analysing musicalparameters derived from a predictive model of human lower cortical,limbic and subcortical neuro-physiological functioning and response tothe pieces of music in order to entrain arousal and direct state of mindand/or affect. Optionally, this may include:

a) choosing a subset of the music in a database by reference to existingdescriptive metadata, if available, such as genre or user-createdplaylist; b) selecting from this subset of music a number of pieces thatwill correspond to the user's initial level of lower cortical, limbicand subcortical neuro-physiological arousal by matching it to musiccontained in the relevant row of the musical effect matrix (we willexplain this matrix in more detail later); c) selecting a target stateof mind and/or affect; d) selecting a series of ascending or descendingmusical effect values which correspond to the expected entrainment pathfrom the initial to the required level of neuro-physiological arousal;e) on the basis of this series of values, selecting qualified contentfrom the music database; f) choosing at random a playlist from thequalified content subject to other rules such as genre preference, theanti-repetition rule (see ‘Musical Selection Algorithms’ below) or theUnites States' Digital Millennium Copyright Act (DMCA) rules; g)repeating the calculation of the playlist at intervals, based oncontinual biometric feedback—for example, the playlist may berecalculated once per minute, based on biometric feedback including themost recent feedback.

5. A method of determining the sufficiency of a (e.g. personal) databaseof music for the entrainment of affect and of then displayinginformation to the user with regard to sufficiency or insufficiency.

6. A method of recommending a complement of musical content for apersonal database of music in order to ensure sufficiency, by usingmusical parameters derived from a predictive model of human lowercortical, limbic and subcortical neuro-physiological functioning andresponse to that music.

7. A method of selecting music which has a similar musical effect, (e.g.according to musical parameters derived from a predictive model of humanlower cortical, limbic and subcortical neuro-physiological functioningand response to the pieces of music). This may include a search by XSystem code.

8. A method of categorising music according to its musical effect ratherthan its descriptive attributes.

9. A method of ordering a series of pieces of music in a playlist bymatching the musical effect of each piece with a temporal series ofvalues described by a musical effect vector.

10. A method of manipulating the arousal of a user by using any of theabove methods or systems.

11. A method to modify the properties of ambient sound in any givenenvironment, in order to produce a desired neuro-physiological responsein the listener, by using any of the above methods or systems. And theuse of this as a selection, control or design tool to define suchresponses.

12. A system adapted to perform any of the above methods.

13. Software (whether device-resident, network resident or elsewhere),firmware, SoCs or audio stacks programmed or adapted to perform any ofthe above methods or to form part of the system described above.

14. A computing device, such as a smartphone or tablet, adapted tomanipulate the arousal of a user by using any of the above methods or byusing or including any of the above systems, software, firmware, SoCs oraudio stacks.

15. Sensors adapted to work with the computing device defined above.

Some more generalised observations now follow:

It is the identification of which structural and experiential phenomenain music activate which parts of the primitive brain, the development oftechniques to measure them using digital signature analysis and theconstruct of a series of generic models that use relatively simpleequations to predict levels of activation of relevant regions and organsof the brain, and in turn their effect on biometric indices, that aresome of the key aspects of this invention.

Examples of the present invention may work with all musical genres anddo not depend upon there being any pre-existing metadata in a databaseof digitised music. The database may be assembled by the user from hisor her own collection and stored on a local playback device, in whichcase the music on the database may be profiled remotely, it may besupplied pre-analysed on a digital storage device, or it may be streamedfrom a central server. In these latter cases, the music may beassociated with other data and/or digital media in order to enhance theuser experience, or signature excerpts may be profiled and included inorder to accelerate the desired effect.

The invention may be implemented as application software on either aremote server, on the music playback device itself or on another devicethat is connected to the music playback device either directly or viaeither a local or wide area network, or firmware or embedded in a chip;it may form part of an audio stack or may be used as part of a set ofdesign tools. These implementations may enable real-time analysis ofmusic tracks and other sounds, all done locally within a portablecomputing device such as a smartphone or tablet, or remotely on aserver, or some combination of distributed local and server basedprocessing. All such deployments will also support a consistent API toenable application vendors and service providers to access systemcapability, for example, to enable new application to be constructed anddeployed.

If the necessary metadata are available, a preferred musical style maybe chosen among those on the music database; if not, the system mayselect from the whole music database rather than a chosen subset.

The following terms are taken to have specific meanings in thisdocument:

‘Level of neuro-physiological arousal’: an index calculated, forexample, as a function of galvanic skin conductivity and pulse rate,though other parameters may also be selected including where morecomplex measurement is required. Different levels of neuro-physiologicalarousal facilitate different activities, states of mind and affect.

‘State of mind’: the dynamic relationship between functional areas ofthe brain associated with different types of thought such as creativity,learning, meditation, imagination etc.

‘Affect’ (noun): as used in psychology to mean feeling or emotion and inpsychiatry to mean expressed or observed emotional response. Mood.

‘Musical Effect’: the state of mind or mood that is provoked by a givenpiece of music and the influence it has upon neuro-physiologicalarousal.

‘Sound’: includes any sound, including music as that term isconventionally understood but also extending to other sounds such as theambient or background noise in a workplace, cinema, home, shop, vehicle,car, train, aircraft: anywhere where sound can in theory effect listenerarousal. For example, tuning car exhaust notes would be one example;modifying engine sounds another. Sounds of nature (wind, ocean etc.),sounds of animals, sonifications (planets, stars, flowers, trees,financial markets, cell activity etc.) are other examples of ‘sounds’.In this document, we will refer to ‘music’, but that term should beexpansively construed to include not merely music in the sense of theart form in which voices and/or instruments are combined to giveharmony, beauty or self-expression, but also all other forms of sound,as that term is expansively defined above.

A note on terminology: The primary auditory cortex is situated in thetemporal lobes of the neo-cortex—the most “evolved” part of the brain,but it is essentially “low” in the system and hence ‘lower cortical’.Organs critical to X-System, such as the hippocampus and amygdala aregenerally described as “limbic” (from the Latin “limen, liminis”,meaning “threshold”, i.e. at the lower limit of the neo-cortex). Theseare close to emotion-related areas such as the nucleus accumbens, andperiaqueductal grey, sometimes also regarded as limbic. The limbicsystem may also be described as the archicortex and paleocortex—the“main, initial or ruling” and “old” cortex. Finally, many X-System areasrelated to rhythm, core emotion and movement are sub-cortical, forexample the basal ganglia and cerebellum.

X-System therefore relates primarily to lower cortical, limbic andsub-cortical areas of the brain, concerned with fundamental anduniversal responses to music, as opposed to more cognitive-related,culture-related and reflective areas of the neo-cortex.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows a graphical representation of the neural elements involvedin audio processing applicable to the X-System. Elements enclosed withinthe solid boxes are part of the current model; elements contained in thedashed boxes may be included in the model.

FIG. 2 shows an overall system construction where the user of the systemboth selects their desired affect goal and is the recipient of thegenerated output.

FIG. 3 shows an overall system construction where selection of targetaffect is made by a party external to the user of the system.

FIG. 4 shows an implementation of the X-System invention where allaspects of the software reside on the user's PC (the term ‘PC’ should beconstrued expansively to cover any computing device of any form factor,including any device capable of performing computing functions).

FIG. 5 shows an implementation of the X-System invention where a primarymusic library, and analysis software resides on a user PC, with theability to transfer a selection of music to a personal music playerdevice, which then generates a dynamic playlist based on the availablemusic.

FIG. 6 shows an implementation of the X-System invention where anexternal service provider offers an analysis tool via a networkconnection. Audio may reside on either the user's PC or be “streamed” bythe service provider, and a database of stored musical affect may beused to minimise track analysis.

FIG. 7A is a detailed block diagram showing the major components of theX-System audio analysis tool used in analysing harmonicity.

FIG. 7B is a detailed block-diagram showing all of the major componentsof the X-System audio analysis tool.

FIG. 8 is a detailed block-diagram showing the major components of theX-System music playback and monitoring application.

FIG. 9 shows schematically arousal as a function of time, for Excite,Maintain or Relax pathways.

FIG. 10: Modelling of the cochlea and primary auditory pathways isachieved through the use of an A-weighting filter. This attenuates lowerfrequencies and amplifies higher frequencies, dropping off again quicklytowards the upper frequency limit of human hearing.

FIG. 11 shows Beat Energy as a function of time.

FIG. 12 shows Harmonic Energy as a function of time.

FIG. 13 shows Harmonic Cost as a function of time.

FIG. 14 shows Volume as a function of time.

FIG. 15 shows Harmonic Energy as a function of time.

FIG. 16 shows sample categorisation from the Miles Davis repertoire.

FIG. 17 shows an example of other manual categorisations, in whichtracks are further sorted into stable, rising and falling vectors.

FIG. 18 shows an example in which movements from Beethoven symphonieshave been categorized according to the vectors.

DETAILED DESCRIPTION

This Detailed Description has the following sections:

-   A. High Level Concepts-   B. The Innate Neuro-physiological Response to Music (INRM) in more    detail-   C. How X-System is used-   D. The Sensor or Sensors-   E. Musical Selection Algorithms-   F. The Music Player-   G. Diagnostic and streaming software-   H. Manual categorisation-   I. Manual categorisation vectors-   J. Social Networks-   K. Opportunities for Expansion/Enhancement-   L. Benefits of X-System

A. High Level Concepts

There is scientific evidence that music entrains and shapes arousal,state of mind and affect through direct neuro-physiological engagement;this invention concerns the discovery and general method ofdetermination of the Innate Neuro-physiological Response to Music, andincludes a novel method of harnessing this phenomenon. As noted above,this invention is implemented in a product called X-System. X-Systemharnesses the potential of music to effect neuro-physiological changesin listeners, in particular in relation to arousal and counter-arousaland associated states of mind, working at the level of the mostfundamental, innate, neuro-physiological functioning and response of thelimbic, lower cortical and sub-cortical regions of the brain.

It differs from other approaches to music categorization in that it isnot concerned with musical similarity, either by semiotic labelling orthe analysis of acoustic characteristics. It also differs from standardtherapeutic approaches, such as classification of mood.

X-System works through predictive, deterministic modelling of INRM(Innate Neuro-physiological Responses to Music) (Osborne 2009,unpublished), see FIG. 1, and the structuring of pathways towards targetstates of body and mind. Section B explains INRM in more detail. Inbrief, the INRM paradigm assumes a standard interpretation of audition,from the auditory canal to the oval window of the cochlea. The cochleaitself is modelled to reproduce the characteristics of human audition.The paradigm further assumes neural pathways to the inferior collicusand primary auditory cortex. Levels of arousal related to pulse andrhythmicity are predicted through a simple modelling of mirror neuronand pre-motor related systems, including tempo induction and indices ofrhythmic power and density. Other bio-active characteristics of musicmay also be modelled such as the identification of rhythmic patterns inthe right anterior secondary auditory cortex, among others.

X-System additionally models the functioning of Heschls gyms, theposterior planum temporale, superior temporal sulcus and circularinsular sulcus to predict arousal-related qualities of timbre andexponential series-related frequency structures, including octaveequivalences. There are other modelling possibilities such asarousal-related effects among chroma (individual notes of melodies) inthe planum polare using, for example, harmonicity indices.

Finally, general levels of ‘turbulence’ are calculated as a predictionof arousal and counter-arousal in core emotional locations and organssuch as the periaqueductal grey and amygdala.

The predictive arousal and counter-arousal values calculated arecombined to model the process of arousal and counter-arousal in theautonomic nervous system, and associated systems such as the HPA(hypothalamic-pituitary-adrenal) axis.

A sensor may optionally be used to establish the state of arousal of theuser, and music categorised by predictive modelling of the INRM paradigmcan then be streamed/played back to achieve the target arousal state forthat user. In an alternative implementation sensors are not provided.Instead, both initial and target states are self-selected, eitherdirectly or indirectly (such as, for example, by selecting a ‘startsong’ which has an arousal value relative to the user's true currentstate). For example, where the user makes a poor initial selection,he/she might skip from song to song initially until one is found (i.e.by trial and error) that is both ‘liked’ and ‘fits’ with their initialstate. From there, X-System, in a sensor-less implementation, may createa playlist tending towards the desired arousal state based on expectednormal human response.

In another alternative, an implementation is provided for a group ofpeople as a system with software but no sensor, reliant on averageexpected response. An application is for ‘crowd’ applications, where anautomated disc jockey (DJ) would be able to manipulate the mood of acrowd at a party.

Other alternatives include applications controlling the personal audioenvironment by sending emotional cues to the system via sensors, andpolling group emotion via either sensor or sensorless inputs, in orderto entrain the person or group towards a desired response.

Other alternative applications include the search, selection,description, detection, sharing or promotion, of music based on itsneuro-physiological content.

As in the case of all systems and activities related to music andarousal, there are variations in response among individuals, andvariations as a result of extreme or unusual states of body and mind,medication etc. The strength of X-System is that it works on the basisof the most fundamental physiological responses, which may act in anethical and democratic synergy with conscious and unconscious consent ofthe user. A further strength of the INMR-based categorisation system isthat it may be applied to the music of any human culture, and indeedboth to sound design and sounds of the natural world.

B. The Innate Neuro-physiological Response to Music (INRM) in MoreDetail

FIG. 1 shows a simplified model of the neural structures related toauditory processing and interpretation. The X-System example of theinvention may model the functioning or behaviour of these systems inresponse to sound (e.g. musical) stimulus as described in the followingsections.

The Innate Neuro-physiological Response to Music Paradigm is apredictive, deterministic model of the mind and body's most fundamentalresponse to music. Although responses to music are profoundly influencedby culture, personal history and context, there are basicneuro-physiological reactions that are universal to all musicalexperience. A substantial body of recent research in neuro-physiologyand neuroscience, including evidence from functional Magnetic ResonanceImaging, EEG and Positron Emission Tomography, as well as studiesrelated to endocrine and autonomic activity has made it possible tobuild a predictive model of how the lower cortical, sub-cortical andlimbic parts of the brain react to sound.

X-System makes use of the following protocols for audio input. Input istaken from uncompressed WAV files or any other suitable format (X-Systemcan use lower quality file formats when undertaking remotecategorisation—e.g. categorising music tracks on a remotely held serveror personal device. Equally, higher quality file formats may be moreappropriate in other circumstances). If the track is in stereo, wecombine both channels by averaging them. This is particularly important,for example, for 1960s tracks, where some loud instruments werepositioned full left or right. This should not cause interference unlessthe audio has passed through faulty stereo equipment (e.g. a misalignedtape head). The track is split into sections of a given length, and theanalysis is carried out independently for each section.

FIG. 7A is a block diagram showing the major components in X-System foranalysing harmonicity and FIG. 7B is a block diagram representation ofall of the major components of the musical analysis tool. The operationof the major components will be described in the remainder of thisSection B.

B.1 The Cochlea and Primary Auditory Pathways

Modelling of the cochlea and primary auditory pathways is achievedthrough the use of an A-weighting filter, as specified in IEC 61672.This attenuates lower frequencies and amplifies higher frequencies,dropping off again quickly towards the upper frequency limit of humanhearing; the filter ‘knee’ is at around 6 kHz. This weighting isrequired to ensure that (as in human audition) high energy lowerfrequency sounds do not overwhelm other spectral information. See FIG.10.

B.2 Harmonicity: Heschl's Gyrus and Associated Tonotopic Maps

“Harmonicity” describes the correspondence of sound (e.g. music) to thepattern of the harmonic series (harmonic series are present in the soundyou hear when the winds blows through a hollow tree, run your fingerlightly up the string of a violin or guitar, or blow progressivelyharder on a single note on a flute). The harmonic series is a universalpattern of concentrations of sound energy in symmetrical resonatingobjects: a fundamental tone f, sounds together with its harmonics f2,f3, f4 etc. This pattern has been important throughout the evolution ofsentient life forms, from the harmonic resonance of the primal cell,through the perceived “safety” of harmonic sounds in the environment, tothe pleasing harmonic resonances of musical instruments and the humanvoice. “Harmonicity” or correspondence to the pattern of the harmonicseries is detected by Heschl's Gyms, located in the primary auditorycortex of the brain. Harmonicity activates centres of counterarousal andpleasure in core emotional centres of the brain. Inharmonicity, or lackof correspondence to the harmonic series activates systems of arousal.

X-System models the functioning and response of Heschl's Gyms to soundby determining levels of harmonicity and inharmonicity. This may be acomplex process. Musical structures may involve several fundamentalseach with their own harmonic or inharmonic spectrum.

X-System is unprecedented in that it combines all emotional processingof pitch and timbre in two harmonicity-related algorithms. Timbre (theinternal structure “colour” of a sound), harmonicity (the extent towhich the internal structure corresponds to the pattern of the harmonicseries) and individual pitches are initially processed in the primaryauditory cortex. The main area for processing timbre is the posteriorHeschl's gyms and superior temporal sulcus, extending into the circularinsular sulcus (McAdams et al 1995; Griffiths et al 1998; Menon et al2002). Pitch is processed progressively deeper in areas surroundingHeschl's gyms: chroma (or differences of pitch within the octave, as inmost conventional melodies), activate bilateral areas in front ofHeschl's gyms and the planum temporale, while changes in pitch height(octave transpositions and the like, as in the difference between a manand woman singing the same tune) activate bilateral areas in theposterior planum temporale (Brugge 1985; Pantev et al 1988; Recanzone etal 1993; Zatorre et al 1994; Warren et al 2000; Patterson et al 2002;Formisano 2003; Decety and Chaminade 2003; Jeannerod 2004;Talavage2004). Harmonicity and pitch structures activate areas of the amygdalaand hippocampus, and in turn the autonomic nervous system, coreemotional centres, and endocrine and neurotransmission systems (Wieserand Mazzola 1986; Blood and Zatorre 2001; Brown et al 2004; Baumgartneret al 2006; Koelsch et al 2006). X-System predictively models theneurophysiological sensing of simple timbre (Heschl's gyms, superiortemporal sulcus, circular insular sulcus) by analysing windows ofvertical harmonicity: X-System detects a principal fundamental throughcalculation of the harmonic product spectrum, then establishes degreesof harmonicity both within and among the spectra of differentfundamentals. This analysis is applied both “vertically” toinstantaneous moments, and “horizontally” to progressions of pitches andspectra in time (related to the tonotopic mapping of the area aroundHeschl's Gyms) and expressed in terms of linear harmonic cost.

In one very simple implementation, the mean values of linear harmoniccost (C) and instantaneous harmonicity (H) are combined to calculate theinharmonicity (I) of a piece where:

I=C/10−H

This equation is a non-limiting example of how inharmonicity can becalculated and other ways of linking I to C and H may well beappropriate; furthermore, I may be defined in terms of other oradditional variables, as may C and H. See FIGS. 12 and 13, showingharmonic energy and cost as a function of time.

More details on Harmonicity calculation now follow:

B.2.1 Spectral Analysis

First the STFT of the audio is taken with a window length of 8192samples and an interval of 2250 samples (0.05 seconds). This produces a2D array of time vs frequency.

B.2.2 Cochlear Modelling

As in the case of rhythmic processing, analyses are performed on atransformed instance of the input sample data, which accounts forcertain aspects of the auditory pathway, primarily the cochlea pick-up.The behaviour of the cochlea is well understood and accurate models havebeen developed. We apply a frequency-dependent gain function to theinput signal, which attenuates bass signals and amplifies treblecomponents, with a filter “knee” at around 6 kHz. The exact transformused is the “A Weighting” as specified in IEC 61672.

B.2.3 Fundamental Frequency Detection

For each time slice of the STFT array, the fundamental frequency isdetermined using the harmonic product spectrum method, as follows:

-   Take the frequency spectrum, and produce copies of it compressed    along the frequency axis by factors of 2, 3, 4 and 5.-   Multiply all 5 copies (including the original)-   The fundamental frequency is the maximum value of the resulting    spectrum.

B.2.4 Mean Harmonicity

For each time slice of the STFT array, the mean harmonicity is the ratioof harmonic energy to the total energy present in the slice. Harmonicenergy is energy found in the following harmonics of the fundamental, aswell as of ½ and ¼ of the fundamental: [1 2 3 4 5 6 7]. For each ofthese harmonics, we sum the energy found in the closest STFT bucket,plus 3 buckets on either side.

B.2.5 Linear Harmonic Cost

Predictions of activity in, and progression through, areas surroundingHeschl's Gyrus (planum temporale, posterior planum temporale) includingchroma, octave changes and chord progression etc. are combined in asingle operation, described as “linear harmonicity” or “harmonic cost”.

This is entirely unprecedented: it analyses all melodic and harmonicprogressions in terms of how far each step deviates from the simpleratios of the harmonic series: Linear harmonic cost arises from STFTtime slices whose fundamental frequency differs from that of theprevious slice. Time slices with no change in fundamental have a cost ofzero. The fundamental frequency is first normalised by rounding it tothe nearest musical note value under the A440 tuning, then shifting itto a single octave. The (normalised) fundamental is then compared to theprevious one: If they are identical, the cost is zero.

If the new fundamental is one of the following harmonics andsub-harmonics of the previous (normalised) fundamental ( 1/9 1/7 ⅙ ⅕ ⅓ 36 7 9) then the cost is defined as equal to the multiplier of theharmonic or divisor of the sub-harmonic. Otherwise the cost is definedas 15.

Linear harmonic cost is expressed in terms of cost per second. Themetric therefore represents both the rate at which the fundamental ischanging, and the harmonic distance of the changes. Higher numbersindicate a more stimulating effect.

Linear harmonicity activates similar emotional systems to verticalharmonicity (Wieser and Mazzola 1986; Blood and Zatorre 2001; Brown etal 2004; Baumgartner et al 2006; Koelsch et al 2006).

B.2.6 Harmonicity and Valence

Both vertical and linear harmonicity are powerful indices of valence(Fritz 2009), or whether a sound is “positive” or “negative”, “pleasing”or “not so pleasing”. Linear harmonicity may track the evolution ofvalence indices over time—the principle is simply the more harmonic, themore positive valence, the less harmonic, the more negative valence.

It is conceivable that the Heschl's gyms-related equations may bereconstituted with a different mathematical approach. It is highlyunlikely that the planum temporale function could be approached in anydifferent way.

B.3 Rhythmicity: Mirror Neurons, the Auditory and Pre-Motor Cortex

Human responses to musical rhythm involve a complex set of activationsof mind and body systems (Osborne 1. 2009; Osborne 2. 2009; Osborne 3.2012) including perceptual systems, the dorsal cochlear nucleus,inferior collicus and spinal systems (Meloni and Davis 1998; Li et al1998) the primary and secondary auditory cortices (Peretz and Kolinsky1993; Penhune et al 1999), mirror neurons (Rizzolati et al 2001; Gallese2003; Molnar-Szakacs and Overy 2006; Overy and Molnar-Szakacs 2009),pre-motor and motor cortices, basal ganglia, vestibular system andcerebellum (Zatorre and Peretz 2001; Peretz and Zatorre 2003;Turner andIoannides 2009;), the autonomic nervous system (Updike and Charles 1987;Iwanaga and Tsukamoto 1997; Byers and Smyth 1997; Cardigan et al 2001;Knight and Rickard 2001; Aragon et al 2002; Mok and Wong 2003; Lee et al2003; Iwanaga et al 2005), and finally somatic and core emotionalsystems (Holstege et al 1996; Gerra et al 1998; Panksepp and Trevarthen2009). Some of these may be related in particular to the firing ofmirror neurons capable of regenerating perceived behaviours, vitalityaffect and energies encoded in the sound and its manner of performancein the mind and body of the listener. Fast rhythms of high energyactivate arousal in both the Autonomic Nervous System and endocrinesystems such as the HPA axis. Slow rhythms activate counterarousal.

X-System detects a basic, “default” rhythmic pulse in terms of beats perminute. There are often difficulties in establishing metre, but X Systemapproximates the arousal effect of metrical structures by averaging theaccumulation of power of rhythmic events over time. The power of arhythmic event is defined as the ratio of the energy before the beat tothe energy after it. In one very simple implementation, the beats perminute value (B) is combined with the mean of the beat strength (S) toproduce a value for rhythmicity (R) where:

R=√B*S{circumflex over ( )}2

This equation is a non-limiting example of how rhythmicity can becalculated and other ways of linking R to B and S may well beappropriate; furthermore, R may be defined in terms of other oradditional variables. R, in general, may be a function of B and S, butthe optimal relationship will depend on various factors. See FIG. 11,showing beat energy as a function of time.

More details on Rhythmicity:

B.3.1 Cochlear Modelling

As explained earlier, aural perception of rhythm is predicted throughconventional cochlear modelling: Following audio input, all subsequentanalyses are performed on a transformed instance of the input sampledata which accounts for certain aspects of the auditory pathway,primarily the Cochlea pick-up. The behaviour of the Cochlea is wellunderstood and accurate models have been developed. We apply afrequency-dependent gain function to the input signal, which attenuatesbass signals and amplifies treble components, with a filter “knee” ataround 6 kHz. The exact transform used is the “A Weighting” as specifiedin IEC 61672.

B.3.2 Rhythmic Induction

The activations of primitive spinal pathways and the pre-motor loop(including basal ganglia, vestibular system, cerebellum etc.), allconcerned with primal responses to rhythmic impulses, are predictivelymodelled by beat induction, using a specifically calibrated onsetwindow.

Rhythmicity is, of course, a parameter that models the basic tempo ofthe sample, as well as higher order metrical structures within. It iscomputed by first determining note onsets, using spectral flux peakdetection. These onsets are then used to generate and score a largenumber of metrical structure hypotheses. Candidate hypotheses aregenerated, filtered, and scored, using the methods of Dixon [Evaluationof the Audio Beat Tracking System BeatRoot, Journal of New MusicResearch, 36 (1), 39-50, 2007]. In addition to the methods describedtherein, we extend the process to include the magnitude of the spectralflux surrounding the onset event in order to estimate higher orderstructure. The hypotheses generated are filtered and scored using thesame methods, with the final output comprising an estimate of thefundamental tempo of the sample, a secondary output in which the tempois weighted according to the predicted metrical structure, in which themore distinct an accented beat is from the base beat, the higher thisvalue. A confidence value is also expressed as the variance of thedistribution of these outputs for all beat hypotheses scoring above agiven threshold. This confidence value is normalised to permitcomparison across samples.

B.3.3 Auto-Correlation

Rhythmic pattern recognition and retention (for example in the secondaryauditory cortex of the temporal lobes) is predictively modelled byself-similarity/auto-correlation algorithms (e.g. Footehttp://207.21.18.5/publications/FXPAL-PR-99-093.pdf.)

First the audio is Hamming-windowed in overlapping steps; the log of thepower spectrum for each window is calculated by means of DFTs (discreetFourier transforms). these coefficients are perceptually weightedthrough Mel-scaling. Finally a second DFT is applied to create cepstralcoefficients. High-order MFCCs (Mel-frequency cepstral coefficients) arediscarded, leaving the 12 lower-order MFCCs, forming 13-dimensionalfeature vectors (12 plus energy) at a 100 Hz rate. These data are thensubjected to vector autocorrelation, plotted in a two-dimensionalwindow, where both x and y axes plot the unfolding of the track in time.Areas of “brightness”, reading upwards, for example, from the firstinstant of the track on the x axis, indicate points of similarity, andlikely metrical structures.

Density of distribution of points is also used in a predictive index ofrhythm-induced arousal (the greater the density, the higher thearousal).

B.3.4 Power

Activation of mirror neuron systems, which detect, among other things,the power, trajectory and intentionality of “rhythmic” activity, ispredictively modelled through indices of rhythmic power, includingcomputation of volume levels, volume peak density, “troughs”, or theabsence of energy and dynamic profiles of performance energy.

B.3.5 Volume Envelope Analysis

The volume envelope is calculated as the RMS of 5 ms slices of theamplitude data.

B.3.6 Volume Level

This is simply the mean RMS level over the time period.

B.3.7 Volume Peak Density

Number of volume peaks per slice (usually 10 seconds), as found by theMATLAB findpeaks function with minpeakdistance=100 ms, multiplied by themean height of the peaks above the volume mean, divided by the volumestandard deviation.

B.3.8 Volume Differential Peak Density

As Volume Peak Density but taken on the first differential of thevolume.

B.3.9 Volume Trough Length

The average durations for which the volume is lower than half a standarddeviation below the volume mean.

B.3.10 Volume Trough Minima

The mean of the volume minima of volume troughs divided by the volumestandard deviation.

B.3.11 Dynamic Profile

In addition, the profile of expenditure of energy (precipitous for higharousal, smooth for low) before and in between onsets, which appears tobe important mirror neuron information, will in future be predicted bycomputation of profiles of energy flow leading to significantarticulations.

For example, τ“tau” coupling (Lee 2005):τx=Kx,g τg

where tau=time at origin of glide (end of previous onset), x=the gappreceding the next detectable onset, g=a patterned flow of electricalenergy through an assembly of neurons, kappa=movement value determinedby the brain. Profiles of energy will be determined by profiles of meanvalues of kappaXG.

B.3.12 Standard, commercially available software for rhythm detectionmay be used satisfactorily for some genres of music, but such softwaremay fail to detect the specific bio-activating rhythm of any given pieceof music and may even have difficulty in detecting rhythm at all insome. The above algorithms, which predictively model the activations ofcore rhythmic processing centres of the brain, have proved reliable.Some of these algorithms, for example beat detection, could in theory bereplaced by other mathematical procedures. The originality of theinvention lies in the unprecedented nature of the biological modelling.Thus we have a phenomenon in music (rhythm) that is known to have aneffect on arousal and counter-arousal in the autonomic nervous system(as well as core emotional systems, endocrine activity andneurotransmission), which in turn is known to have a powerful influenceon how you feel: relaxed, able to concentrate, wanting to dance etc. Wealso have a means of measuring the effect of the rhythm (our sensor).Our categorisation algorithms (above) take as an input the relevant datafrom the digital signature analysis and yield as an output a predictedimpact on the chosen biometrics. Intense rhythms will have an arousingeffect while gentle rhythms will have a calming effect, and there is noshortage of prior art based on the same principle. In modelling theinnate neurophysiological response to rhythm an algorithm linking thismeasurement of rhythm to its expected effect on (in this embodiment)heart rate and galvanic skin conductance is hypothesised, tested andrefined.

B.4 Turbulence and Core Emotional Systems (Locations and Organs)

The ‘turbulence’ of a piece of music relates to the speed and extent towhich it changes over a period of time, in terms of rhythmicity andharmonicity as well in terms of general fluctuations in sound pressure.

‘Turbulence’ combines indices of change in rhythmicity and harmonicity,related to pathways described above, with auditory brainstem andcortical activity innervating the amygdala, hippocampus and coreemotional regions affecting neurotransmission and endocrine systems,including the HPA axis, dopamine circuits and levels of, for example,norepinephrine, melatonin and oxytocin (Miluk-Kolasa et al 1995; Gerraet al 1998; Kumar et al 1999; Evers and Suhr 2000; Schneider et al 2001;Blood and Zatorre 2001; Grape et al 2003; Uedo et al 2004; Stefano et al2004; Herbert et al 2005; Nilsson et al 2005). This important predictorof arousal and counterarousal may be represented as the differential ofrhythmicity and harmonicity.

‘Turbulence’ is therefore a measure of rate of change and extent ofchange in musical experience. These factors seem to activate coreemotional systems of the brain, such as the amygdala and periaqueductalgrey, which are in turn linked to autonomic and endocrine systems. Athigh levels of musical energy turbulence may enhance arousal; at lowlevels it may add to the counterarousal effect.

The total turbulence (T) of a piece is determined as a combination ofthe turbulence of the harmonicity (H′) of the piece and the energypresent during peaks of volume of the track (P). Turbulence ofharmonicity is calculated as the standard deviation of the differentialof the harmonicity, divided by the mean of the differential.

In one very simple implementation, total turbulence is calculated as:

T=dH/dt*P

This equation is a non-limiting example of how turbulence can becalculated and other ways of linking T to H and P may well beappropriate; furthermore, T may be defined in terms of other oradditional variables.

See FIGS. 14 and 15, showing volume and harmonic energy as a function oftime.

B.5 Combining Values

Each of the algorithms described above, hypothesised and refined throughtesting, has effectively become a ‘virtual organ’ of the brain thathelps us predict the effect on levels of arousal and counter-arousal ofpatterns that can be detected in music using digital signature analysis.The relative weighting of each ‘organ’ may be adapted using heuristic,machine learning or other techniques to calibrate the overall predictivepower of the set of ‘virtual organs’ working in harmony.

Any subset of the above analyses may be combined together to produce asingle number estimating where a piece of music (or part thereof) lieson the scale from relaxing to exciting. The formula used to perform thiscombination may be derived from experimental data, as follows: A numberof human listeners listen to the same selection of tracks. Each listenerthen independently ranks all the tracks in order from what they considerthe most relaxing to the most exciting. (The ranking could also be doneobjectively by measuring the listeners' physiological data, but this hasso far given much less consistent results across listeners.) Astatistical regression analysis is then carried out, with the averagehuman ranking as the dependent variable, and the chosen subset ofmusical analyses as the independent variables. In other words, a singleformula is produced which uses the analyses to predict the humanrankings. The coefficients in this formula are chosen to give the bestpossible prediction, considered over all tracks. The resulting formulamay then be used to produce automated predictions on a mass scale for amuch larger number of tracks. Consider the following example data:

Average human Mean harmon- Volume level Rhythmicity Track ranking (0-1)icity (mh) (vol) (rhy) 1 0.2 0.212 0.010 118 2 0.4 0.231 0.069 228 3 0.50.204 0.123 187 4 0.6 0.225 0.294 130 5 0.8 0.173 0.163 155

Any statistical regression method may be used to produce the overallformula. For example, if we use multiple linear regression with theordinary least squares estimator, we obtain the following:

Predicted ranking=−6.59*mh+1.63*vol+0.0018*rhy+1.36

Non-linear transformations of one variable (e.g. logarithm orreciprocal) or non-linear combinations of multiple variables (e.g. theirproduct or ratio) may also be used, by pre-calculating them and thentreating them as additional variables in the regression.

The coefficients employed in each of the algorithms, and the relativeweighting of the algorithms in combination, may be optimised fordifferent musical styles using metadata (such as genre and artist) thatare typically carried alongside music distributed in digitised formatssuch as the Compact Disc and over the Internet. With the accumulation oflarge amounts of (anonymised) human response data that may be fed back(with the consent of the listener) in networked deployments of X-Systemit will be possible to fine-tune the relative weighting of both theequation coefficients and their relative weighting in combination toimprove accuracy. Similar optimisation of coefficients and weightingswill be achieved by analysing user data in combination with the musicmetadata (such as genre and artist) that are typically available withmusic distributed in digital formats, and in due course thisoptimisation will be extended to both the individual user and specificrecordings.

The overall arousal index calculated for each piece of music may beexpressed either as a single number that describes the overallneurophysiological effect of listening to it from start to finish, or itcan be displayed graphically with arousal index on the vertical axis andtime on the horizontal axis. The resulting trace would effectivelydescribe the neurophysiological journey a listener may expect as theylisten from beginning to end. This latter is likely to be of particularuse in longer and more complex pieces of music such as much of theclassical repertoire, whereas some other repertoire such as modernWestern pop music might more conveniently be represented by a singlenumber. In either case, the effect of a piece of music is both inherent(in that it is a product of the patterns detected in the music) anddependent on the state of the listener (in that the neurophysiologicaleffect of music is relative rather than absolute [Altshuler ‘TheIso-Moodic Principle’ 1948]).

As we learn to navigate the brain in greater depth and detail, and assensor technology develops further, different equations will bedeveloped to predict the effect of different musical structures ondifferent measurable outputs. All these instances of the application ofthe Innate Neurophysiological Response to Music are intended asdifferent implementations of the present invention, which claims a novelsystem and method of predicting the effect on universal humanneuro-physiology of any piece of music from any musical tradition bymeans of analysing bio-activating patterns in music and usingmathematical equations tailored to specific biometric indices to predictthe effect of these musical patterns on the chosen biometric indices.

B.6 This section describes an alternative approach to combining valuesfor rhythmicity, inharmonicity and turbulence to produce an excitement(E). In this alternative approach, E is given by:

E=(10*I*R)+T

This equation is a non-limiting example of how excitement E can becalculated and other ways of linking E to I, R and T may well beappropriate; furthermore, E may be defined in terms of other oradditional variables.

This generally produces a number from between −1 and 7, representing therange of the counterarousal-arousal scale. Currently the thresholds forfive arousal categories are approximated as

−1 to 0.6=1

0.6 to 2.2=2

2.2 to 3.8=3

3.8 to 5.4=4

5.4 to 7=5

An alternative is an equation where rhythmicity and harmonicity aremultiplied and turbulence added. In other examples, log scales andFibonacci progressions may be used in the analysis of auditory data.

More detail: For each of R, H and T, X-System records both a singleaverage value (μR, μH, μT) and a profile of variation furthercategorized as ascending, descending or stable (ΔR>0, ΔR<0, ΔR=0; ΔH>0,ΔH<0, ΔH=0; ΔT>0, ΔT<0, ΔT=0).

The average values of R, H and T are mapped (in the simplest case thenormalised mean is taken) to an n dimensional point p characterisingphysiological state. The variations of R, H and T are also mapped(again, in the simplest case the normalised mean is taken) to another ndimensional point q characterising the directional effect these valueswill have on the physiological state.

The concatenation of p and q allows each musical excerpt to be mappedonto a Musical Effect Matrix M, a 2*n dimensional matrix, n dimensionscorresponding to the physiological parameters measured by E representinggranular ranges into which E can fall, the other n dimensionscorresponding to the effect the track will have on the physiologicalparameters (ascending, descending or maintaining any given physiologicalparameter or dimension of E).

We now describe in more detail how the Music Effect Matrix M isgenerated. As noted earlier, FIG. 7A is a block diagram showing themajor components in X-System for analysing harmonicity and FIG. 7B is ablock diagram representation of all of the major components of themusical analysis tool. The values output by the analysis are specifiedas functions in t, the time index of a particular measurement. Thesevalues (corresponding to R, H and T) are grouped as follows:

X(t): values for rhythmic “presence”, tempo, power and density ofpulse-related rhythmic structures, and harmonic rhythm—related tocerebral cortex activity, core emotional locations, and autonomic andendocrine responses.

Y(t): degree of conformity, within the limits of human perception, toexponential series-related frequency structures in melody andharmony—related to the cochlea, Heschl's gyms and cerebral cortexprocessing, core emotional locations and autonomic and endocrineresponses.

Z(t): the rate and magnitude of variation in X(t), Y(t) and dynamicpower (W(t)) which is measured using the normalized, gain adjustedvolume level—related to activation of core emotional systems, and theendocrine and autonomic nervous systems.

Categorization may be preceded by aggregation, documenting provenance,genre and other data for music tracks. This may be according to anindustry standard such as that provided by Gracenote®, it may be theresult of individual user editorial, crowd-sourcing methods such ascollaborative filtering, or may be the result of future aggregationstandards based on, for example, digital signature analysis. The purposeof aggregation is to allow the user to choose a preferred musical style,though it is not strictly necessary for the proper functioning ofX-System.

In order to reduce the computational cost of analysing a piece of music,only certain regions are examined. The location and length of theseregions are determined dynamically, based on configurable parameters andan adaptive mechanism that recursively examines regions with a largerate of change. This produces a sparse array of values for eachfunction, identified by a time index. Due to the recursive analysis, thestep size _t will vary over the function domain t.

Algorithmically, these regions are generated by applying a windowingfunction to the incoming audio data. The sampling window is then“stepped” over the region, and the results of each step are aggregatedto form the single output at time t. For example, a region may consistof the (absolute) time interval (0 s; 1 s), which is further windowedinto 50 ms samples, with a 10 ms step size. This produces a total of 96sample points, which are combined to form a single value X(0)=x.

The analysis of X(t) is performed by an “acoustic streaming”—basedrhythmic induction, combined with pattern-recognition and an index ofpower and density.

Rhythmic induction is performed using two main techniques; band-limitedpower spectral density onset analysis, and adaptive comb filtering. Theresults of both techniques are then subjected to a number of heuristicsbased on music theory, and are combined to form a single estimate of themusical rhythm.

Heuristics include rules such as the minimum and maximum plausibletempos or some form of probability distribution of likely tempos for agiven input genre if known. They may also include emphasis andde-emphasis of certain frequency bands based on the input.

Spectral Density Onset Analysis uses a sequence of short-time Fouriertransforms of the windowed samples to calculate the energy present inspecific frequency bands. This data is tracked temporally to observepeaks in bands, which characterise rhythmic events.

Comb Filtering involves convolution of the input signal with a varietyof impulse trains of different spacing, on the basis that as the impulsespacing approximates the rhythm of the input, the overall convolutionresult will increase. This technique can then be used recursively to_find a best-fit impulse spacing which characterises the input rhythm.

Values for Y(t) are established by means of an adaptation of auditoryscene analysis. The audio input data are passed through a gammatonecochlear filter bank, splitting them into multiple streams. For eachstream, special, frequency and onset information is calculated.

Spatial information is acquired from stereo tracks of each stream,frequency peaks are calculated using a Fourier transform and onsetdetector maps are applied to find the starts of sound elements.

This information is combined and correlated to partition the audio datainput into sound sources. For each of these sound sources a number iscalculated as the ratio of sound energy within the harmonics of itsfundamental frequency to the sound energy outside the harmonics of itsfundamental frequency. Y(t) is the mean value of the ratios for eachsound source from the excerpt.

The fundamental frequency is determined using a Harmonic ProductSpectrum, in which the signal is repeatedly multiplied with down-sampledcopies of itself, causing a large peak to occur in the frequencyspectrum corresponding to the fundamental frequency. Standardsignal-processing techniques are also applied to de-noise the resultantoutput.

Z(t) is measured as the rate and magnitude of variation in X(t), Y(t)and W(t).

In each of these cases (X(t), Y(t) and Z(t)) the system records both asingle average value (μX, μY, μZ) and a profile of variation furthercategorized as ascending, descending or stable:

-   Ascending—An overall positive trend in the functions X(t), Y(t) and    Z(t).-   Descending—An overall negative trend in the functions X(t), Y(t) and    Z(t).-   Stable—Only minor deviations from the mean μ result over the audio    input signal.

The average values of X, Y and Z are mapped (in the simplest case thenormalized mean is taken) to an n dimensional point p characterizingphysiological state. The variations of X, Y and Z are also mapped(again, in the simplest case the normalized mean is taken) to another ndimensional point q characterizing the directional effect these valueswill have on the physiological state.

The concatenation of p and q allows each musical excerpt to be mappedonto the Musical Effect Matrix M, a 2n-dimensional matrix, n dimensionscorresponding to the physiological parameters measured by E representinggranular ranges into which E can fall, the other n dimensionscorresponding to the effect the track will have on the physiologicalparameters (ascending, descending or maintaining any given physiologicalparameter or dimension of E).

C. How X-System is Used

As noted above, X-System may use a subject's biometric data (where asensor is available) to measure neuro-physiological arousal. It thenleads the subject by stages towards a target level of such arousal,state of mind and/or affect. This is achieved with a database of music,previously categorised using predictive modelling of innateneuro-physiological responses. Categorisation in real-time or nearreal-time is also possible. Categorisation can be visually displayed(e.g. on the display of the computing device used for music playback);this can include a display of the E values for each music track, or howthe E (Excitement) value changes during a track; R, I, H, C and Tparameters can also be visually displayed. A piece of music thatpredicts or matches the subject's current level of neuro-physiologicalarousal is selected and a playlist constructed on the basis of thefundamental musical effect of each constituent piece of music. Listeningto the playlist directs or moves the user towards the desired level ofarousal, state of mind and/or affect by unconscious neuro-physiologicalentrainment with the music and enables that level to be maintained. Thesubject's current level of neuro-physiological arousal can also bevisually represented, as can the convergence to the desired targetstate.

X-System is, in one implementation, designed to sense the state of mindand body of the user and stream music of selected repertoires to achievetarget states such as:

-   Excitement-   Relaxation-   Concentration-   Alertness-   Potentiation of physical activity

See FIGS. 2, 3 and 9, for example.

C.1 Components in the X-System

X-System includes:

-   automatic categorisation software capable of categorising music of    all cultures either remotely or in proximity according to specific    levels of arousal and counterarousal; these categorisations may be    offered for general use independently of the sensors and diagnostic    software. This may be based on Nigel Osborne's INRM (Innate    Neuro-physiological Response to Music) paradigm.-   a database of music categorised manually or automatically (using the    automatic categorisation software) to achieve specific levels of    arousal and counterarousal-   sensors to detect physiological indicators of arousal (such as    excitement) and counterarousal (such as drowsiness), including heart    rate and galvanic skin conductance-   diagnostic software which employs sensor data to monitor levels of    arousal and counterarousal in the user-   music playback/streaming (eg. playlist selection) software which    selects previously categorised music from a database to stream    appropriate repertoire to achieve target states of mind and body by    a process of step-by-step entrainment, starting from the current    diagnosed “state”; progress towards these goals is monitored by the    diagnostic software. Specific tracks for a listener may be selected    for playback (by streaming or otherwise) according to bio-feedback    from that listener; the playlist may be created locally and the    music tracks requested for streaming/download etc; it is possible    also for the bio-feedback and desired “state” information to be sent    to a remote music server and for that server to generate the    appropriate playlist and provide music tracks to the local, personal    playback device. In this variant, the personal playback device need    have no local music library or X-System software/firmware etc.,; it    needs only the ability to detect the listener's audio preferences    and bio-feedback data and to relay that back to the remote server    using a low capacity back-channel and to then receive the music from    the remote music server.

Note that all software may also be implemented in hardware, firmware,SoC, as part of a third party audio stack and in any other convenientmanner.

Appendix 1 is a more detailed description of the components of X-System.

C.2 Practical Applications of X-System

The sensor is intended to measure one or more predetermined parametersof the user's state of mind and body and to communicate this informationto a processor; the processor is designed to select tracks from themusic categorisation data appropriate to lead the user from her/hiscurrent state of mind and body to the intended condition of arousal orcounter-arousal. This combination will allow X-System to:

-   Sense, in real time, the neuro-physiological state of the human mind    and body;-   Analyse the music collection of the consumer;, or any other    collection he/she has access to, such as with a cloud-based or    remote/central server based music service; and-   Calculate and deliver play lists as a function of a desired state of    arousal.

This will enable users to direct themselves to a desired state, such as:

-   Excited and ready to play sports or exercise; for example, to    enhance oxygenation levels for competition or reduce post-surgical    recovery times;-   Relaxed and able to drift off to sleep;-   In a meditative state to support development of insight;-   In a meditative state to support the development of creative    thought; and-   Maintaining focus and able to concentrate.

(for example, to provide support to overcome conditions such asinsomnia, to reduce medication in post-traumatic stress disorder (PTSD)and in mania patients, to develop and to organise memory, categorised byshort, medium and long term need for data retention.), and to create astate in which to encourage creativity and imagination.

The diagram of FIG. 4 illustrates the current project implementation ofX-System. In an alternative to the implementation of FIG. 4, becauseubiquitous mobile computing blurs the distinction between devices, theelements shown in FIG. 4 within a User PC (music player, music library,automated analysis and musical effect database) may be distributed overtwo or more computing devices. In a commercial example it may also beconfigured to work with portable audio devices: see FIG. 5.

While these components are key elements of X-System, its core innovativetechnology is a definition of the bio-active components of music (basedon a predictive Innate Neuro-physiological Response to Music paradigm,Osborne 2009, eg. see FIG. 1), the algorithms used to calculate thembased on digital signature analysis and the calibration methods used totune the system to the neuro-physiological response of an individual.

D. The Sensor or Sensors

The sensor may be in the form of a wristband, a hand-held or any otherdevice suitable for taking the required parameter measurements. Thesensor may be body-mounted, or use ear buds (e.g. combining a sensorinto ear-bud headphones), remote monitoring via IR or acoustic,wireless, or more generally any form of life sensing. The data capturedpreferably comprises biometric parameters such as heart rate (includingpulse rhythm analysis), blood pressure, adrenaline and oxytocin levels,muscular tension, brain waves and galvanic skin conductivity.Alternative equipment formats include necklaces, bracelets, sensorsembedded in clothing, other jewellery, sensors implanted under skin,headsets, earphones, sensors in handheld form such as covers for phones,MP3 players, or other mobile computing devices.

Sensors currently used in the X-System project comprise a wristbandsensor which will be used to measure galvanic skin response (GSR), and astandard finger clip Pulse Oximeter for the measurement of heart-rateand blood oxygenation. For the purposes of commercialisation thesesensors will be combined in a single, wearable, wireless device. Otherpotential bio-sensors and motion sensors may be included as they becomeeconomically viable.

The sensors must be able to measure a combination of pulse rate and skinconductivity, combined with any other possible measurements and must beresistant to disruption from movements of the user or changes inenvironment; it must also be possible to wear the sensor for extendedperiods of time without discomfort or embarrassment. Other sensorsinclude physical bio-sensors such as oxygenation, EDA, EDC, EDR, ECG,sugar levels, BPM, EEG etc, and multi-spectrum sensors (radio, IR, UV,heat, and broad spectrum), which detect bodily radiation auras.

FIG. 5 shows a desired architecture overview. FIG. 5 shows animplementation of the X-System invention where a primary music library,and analysis software resides on a user PC that is operable, remotely orlocally by the listener or a third party, with the ability to transfer aselection of music to a personal music player device, which thengenerates a dynamic playlist based on the available music.

The X-System sensor measures certain chosen parameters of the user'sphysiological state and transmits the resulting data wirelessly to aprocessor in (or in communication with) a playlist calculator, whichresides on or is otherwise connected to a music playback device (forexample, a personal computer, smartphone, MP3 player or other audiodevice). Transmission is preferably wireless but it will be appreciatedthat other transmission types are possible. Indeed, the processor may beintegrated with the sensor.

The chosen physiological state parameters are denoted by P. A functionF(P) reduces these parameters to a single, normalised point E,characterising the general physiological state of the user. In thesimplest case E is a one-dimensional measurement of the user'sphysiological arousal (or counter-arousal). With further inputs a morecomplex measurement may be obtained, resulting in a point E of ndimensions. An effective prototype has been developed using pulse rate‘p’ and galvanic skin conductivity ‘v’ to calculate a simple index ofphysiological arousal where E=p+v. Currently the prototypes use theNonin X Pod Pulse Oximeter and a skin conductance biosensor. The pulserate, oxygenation and skin conductance of the user are constantlymonitored; heart rate may be used as to control mean variations inconductance. Both sensors currently work independently and are connectedwirelessly to a controlling computer. They may be replaced with a singleintegrated sensor. Alternatively, any other form of wired or wirelesscommunication of sensor outputs to player to output device is possible.Appendix 1 gives more details.

A user initially provides the system with their personal musiccollection (or uses an online library of streamable or downloadablemusic). This is analysed for level of excitement, using INRMcategorisation in combination with signal processing and machinelearning techniques. The user then synchronises this information withtheir music player and selects a level of excitement/arousal; someoneother than the user may also select the excitement level. The sensorwristband provides the system with a constantly updating real-time stateof excitement of the user, allowing the system to react to externaleffects on the user and “catch” them, using the principles ofentrainment to bring them back towards the desired state. Once the userhas achieved the target level of excitement, they are kept there bymusic determined to be effective at maintaining that state.

Although the current version of X-System's sensor is based on heart rateand skin conductance, there are strong arguments for early integrationof other measures, including for example EEG, brainwave sensors. Thiswould allow factors such as concentration, alertness, contemplation,drowsiness or creative flow to be monitored directly through sensing offrequencies of entrained firing of neurons in the brain, rather thanindirectly through indicators of arousal. A second set of relatedchallenges lies in further aspects of machine learning. Individualphysiological responses vary considerably, from person to person,according to time of day, state of metabolism etc. X-System may learnfrom individual users the range of their physiological responses inorder to identify relative levels of arousal, and individually calibratethe diagnostic software. It may also learn about their personalpreferences as already articulated through their choice of repertoire.X-System may also go directly from a set of musical features, using aneural network to predict the effect of these on physiologicalmeasurements, without first reducing the features to an expectedexcitement/arousal level.

E. Musical Selection Algorithms

Certain levels of neuro-physiological arousal are necessary precursorsof activities such as sleep, relaxation, accelerated learning and study,or increased alertness and activity. The user will preferably bepresented with a user interface and choose from a menu of suchactivities in order for the system to establish a target level ofarousal and affect that will facilitate the chosen activity.

The point E, representing the neuro-physiological state of the subjectdiagnosed by the sensor, is used to select music from a database ofmusic tracks indexed by the Musical Effect Matrix M, based on acombination of the granular point r and a direction d pointing towardsthe physiological state towards which the user has elected to move (seepreceding Section E for more detail).

The first piece of music selected will correspond to the initialneuro-physiological state of the subject, represented by E. Subsequentpieces are selected based on their values in M such that each would,played in order, be capable of progressively leading the subject's statetowards the target state. The order in which the pieces of music areeligible to be included in a playlist is determined by a vector thatrepresents a temporally-organised ascending, or descending asappropriate, series of musical effect values in M. The set of pieces ofmusic in the database that meet the requirements of this series ofeffect values is known as ‘Qualified Content’.

The Qualified Content is arranged into an actual playlist according to aset of rules, including but not limited to random selection,anti-repetition, genre preference or some other heuristic. In some casesit may be appropriate to comply with the US Digital Millennium CopyrightAct (DMCA).

Where a sensor is used, then a biofeedback loop is established in orderto ensure continual recalculation of the playlist to compensate fordistraction, individual sensitivity and other factors based upon anydimensions of overall affect that are susceptible to continualmeasurement. Direction towards non-measured parameters of state of mindand/or affect will still occur despite the lack of a bio-feedback loopbecause neuro-physiological arousal is a necessary precursor to state ofmind and affect and establishes the conditions under which the listeneris most susceptible to these other aspects of overall musical effect.

Once a piece of music has been played it is preferably removed from thelist of potentially available content for a minimum number of cycles inorder to avoid unnecessary repetition. This anti-repetition rule issubject to a feasibility test in order that a message of appropriateseverity may be displayed to the user warning of insufficient content orvariety of content in the music database to enable effective functioningof the system along with a suggested remedy such as a recommendation offurther pieces of music which might be added to the database to improveits functioning.

In the case where content has been distributed pre-categorised or whereit is streamed from a central server, playlists may be calculatedinitially in a dynamic mode where shorter excerpts are taken from thedatabase. Once the listener has achieved the target level of arousal,longer excerpts are admitted into the qualified content pool for thepurpose of playlist calculation and the system may enter maintenancemode. Any disturbance which causes the listener's level of arousal tovary by more than a predetermined factor may cause the system tore-enter dynamic mode and re-calculate the playlist based upon shorterexcerpts in order to entrain the listener back to the target conditionat an accelerated rate.

The anti-repetition rule as applied to shorter excerpts may be used tocalculate the minimum required catalogue size on the basis of the numberof separate musical styles that may be selected by the user, the averagelength of a shorter excerpt, the minimum number of cycles that must passbefore the anti-repetition rule will admit a song or excerpt back intothe selection pool and the number of shorter excerpts available thatfall within the least-populated cell of the musical effect matrix.

F. The Music Player

The music player may be an adaptation of standard industry software suchas the

Windows Media Player which is capable of building dynamic playlistsaccording to the Musical Selection Algorithms and of offering the useradditional utility such as selection of musical style, display ofassociated metadata and video content.

The music player may also be a software application which isdownloadable from a software application store accessible via theinternet. FIG. 8 summarises a design of the player system and theintegration with the sensor subsystem. In an implementation, a playersystem and subsystem may be distributed across two or more computingdevices; ubiquitous computing methods allied to mobile computing andpersonal human inputs may be employed, together with multiple ways ofprocessing and delivering audio outputs, both private and public. So notonly players, but also processors and human interaction devices,including but not limited to entrainment of interaction and control of apersonal environment by emotional cues, as well as ordering orsequencing consumption may be used in an implementation.

G. Diagnostic and Streaming Software

When a sensor is used in System-X, then diagnostic and streamingsoftware is capable of reading the values from the sensor(s) anddetermining a state of arousal of the user. The nature of skinconductance means that the absolute value can vary significantly due tohow well it is in contact with the skin, from person to person andthrough normal sweating. To rectify this, the skin conductance value maybe calibrated automatically based on the heart rate of the user.

The user of the system wears the system, selects a repertoire of musicthat they would like to listen to, decides what excitement level theywould like to get to and puts on the sensors. Once a diagnosis has beenmade for the state of arousal of the user, this data along with theselected excitement level is used to select a program of tracks from therepertoire.

Optionally, the user selects a repertoire of music e.g. Jazz, Classical,Indian, World, Baroque), decides what their target arousal level shouldbe (e.g. relaxed, excited, steady) and puts on the sensors. Once adiagnosis has been made of the current state of arousal of the user,repertoire is automatically selected to lead or “entrain” the listenerfrom their current state to their chosen state of arousal. This isperformed by defining a playlist, which entrains the user from thecurrent emotional position in the multi-dimensional space defined by theINRM parameters, moving in small steps towards the defined position inINRM space defined as the desired end point.

H. Manual Categorisation

In an example, the repertoire has been categorised manually by acombination of pulse/metre detection using a metronome, and intuitivepredictive judgements concerning levels of arousal and counterarousalassociated with various musical parameters including rhythmicity,harmonicity, turbulence etc. e.g., the faster the pulse/metre the higherthe arousal, the higher the harmonicity the lower the arousal. In thesample categorisation of FIG. 16 (from the Miles Davis repertoire)tracks are placed in one of five categories corresponding to levels ofactivation/arousal.

I. Manual Categorisation Vectors

By way of example, in other manual categorisations tracks are furthersorted into stable, rising and falling vectors, e.g. “category 4 rising”will be selected if the user chooses a target state of highactivation/arousal; “category 4 stable” would be selected if the useswishes to remain in a state of moderate activation. For an example, seeFIG. 17.

In the example of FIG. 18, movements from Beethoven symphonies have beencategorized according to the vectors. Note that no movement wasidentified as appropriate for 4/stable or 2/stable.

Examples of the present invention have been described with reference toits effect upon human beings. However, the effect of music on animals iswell documented. This almost certainly depends on simple psychoacousticeffects of sound environment, rather than a musical/biological discourseas such, but examples of the present invention may see applications inanimal husbandry or veterinary medicine in addition to both generalconsumer, professional, athletic, wellness, healthcare and othermarkets.

J. Social Networks

In this application, X-System is adapted to facilitate the communicationof neurophysiological state, arousal, affect and valency data,determined by X-System's algorithms, to friends via short range wirelessand Bluetooth networks, as well as more widely to social networks suchas Facebook and Twitter, and to health and care workers, as adiagnostic, monitoring or entrainment tool.

This application enables a range of navigational and communicationapplications on smartphones and other devices, allowing users to‘communicate and navigate innate states of arousal’ (mood or emotion)and ‘communicate and navigate experience’. It enables individualX-System users not only to see displays showing their own innate states,but to allow others to ‘read’ their true or unconscious states as theyexperience a variety of activities, from listening to music, to sportsand recuperation and post-surgical care in health care settings.

A system and method for communicating X-System diagnostic capacity todecode neurophysiological states, adapting it to facilitate deeper, moredirect communication about states of arousal and valency whilst engagingin a wide range of activities (including but not limited to music),between individuals and groups in social networks.

A system and method for generating information requests based on actualstates of arousal (as measured by X-System), to search engines such asGoogle—this arousal information can then be used as an input to thesearch algorithm and also to the algorithms that control whichadvertisements are displayed (so for example, web users may be morereceptive to advertisements for certain products when in specificarousal states and search results and advertisements can be tailored formaximum relevance using arousal state information. The arousalinformation can be used also to indicate ‘presence’ status information(“I am in a good mood, listening to Beethoven” etc.).

X-System categorises the innate neurophysiological ‘state’ ofindividuals in terms of both an unbroken continuum of data and discreetcategories, ranging from 1 (high arousal) to 5 (counter-arousal). Thisis linked in core X-System applications to music selection.

In this ‘social networking’ or ‘sharing’ application, the innate ‘state’arousal/counter arousal and valency data of an individual is transmittedover a variety of standard communication networks (including but notlimited to Wi-Fi, Bluetooth, GSM, and other Mobile networks andfixed-line Internet) both directly and via wider social network systems(such as Facebook), to enable peer to peer and one to many communicationof arousal, together (optionally) with coding that indicates concurrentmusic or other entertainment selection, or self-declared activity (‘thisis me watching a movie; responding to an advertisement; walking in thecountry; running, cycling’), all in real time, or near real time. Forexample, X-System detects emotional arousal parameters information of anaudio track and then embeds this information into the audio track orinto an electronic link to the audio track or as metadata associatedwith the track.

The X-System ‘state’ data can be distributed in real time snapshots(arousal and valency now); in real time streams (continuous flow); ashistory (arousal and valency yesterday), with or without data about themusic selected at the time. This might be termed “a personal verveindex” (verve: vivaciousness; liveliness).

The data will then be displayed as graphics, as colour codes, or in avariety of statistical forms. Users will be able to annotate the dataand music with ‘activity labels’ (I was running at the time, or doinghomework), which will open up other forms of analysis of therelationships between arousal, valency, music, other entertainmentexperiences and activity.

This application will enable individuals to search for people in theirsocial networks who are in a similar mood, or engaged in similaractivities, such as ‘find people in my network who want to talk’ orfeeling down and yet keen to talk. This can be indicated by mood boardsor to augment presence information on Facebook and other socialnetworks.

With large volumes of users expressing their mood automaticallygenerated by people who opt in (subject to say anonymity rules andpermissioning about sharing), the data can indicate overall states ofarousal amongst groups and larger communities.

The application will be extended to provide graphical and network mapsshowing patterns and cluster of moods amongst social groups, creating a‘social emotion’ landscape for groups either engaged in their ownindividual activities, or groups together, in a social setting, such asat a party, or listening to a concert, or dancing.

This contrasts with early examples of social network analysis, which arelimited by data mining and pattern matching derived from language andsemantic analysis and so limited in their accuracy. X-System willgenerate more authentic and accurate interpretations of both individualand group arousal by capturing true innate neurophysiological stateinformation.

This application will also be used to optimise web sites by linkingX-System users to web cookies, such that if I am looking at a site andagree to the use of X-System readings of my innate state information,the cookies will generate analysis of the emotional impact of the site,or particular pages. This will enable web designers to experiment with avariety of textual, film, music and screen displays, layouts andexperiences and get immediate feedback about users' emotional response.

This information will then be available to be matched to advertising andmarketing metrics, such that responses to web experiences can be alignedwith brand values and with the desired moods or desires that particularproducts and services aim to create. So, for example, the feedbackmechanism might be used to match the emotional response to anadvertisement about a particular car.

This extension of X-System's core algorithms creates a new form ofcommunication, operating at a deep level, beyond culturally bound,linguistic expressions of mood, optionally linking it to currentactivity including choices of music, other entertainment and otheractivities.

This communication of unconscious, pre-linguistic levels of arousal,affect and valency opens up a new paradigm for social networking andhealth care diagnostics. In care settings, for example, monitoringpatients' ‘state’ information will provide insights otherwise notpossible using conventional diagnostic techniques. X-System may beintegrated with a variety of conventional medical, care and diagnosticdevices and applications to create a more holistic picture of of patientcondition and emotional state.

The X-System core data about innate arousal, valency and music selectionis transmitted via standard interfaces to widely available socialnetworks such as Facebook and Twitter and direct to Smartphones in localnetworks.

X-System will be embedded in Smartphones and other devices, in a varietyof combinations of software, firmware and chip hardware. The X-SystemAPI will enable specialist App developers to create a variety of toolsand techniques to leverage the flow of ‘state’ information, creatingfeedback and monitoring services.

There are many protocols and systems for the transmission of data andinterfaces to social networks and Smartphones. This application ofX-System is unique in that it enables these systems to be extended withnew data that is otherwise not available. X-System is extended to targetcommunication of innate arousal and valency with accompanying dataindicating concurrent music, other entertainment or self-declaredactivity to individuals and groups in local, wide area and socialnetworks.

X-System can also share arousal values, associated with a userinteracting with a search engine such as Google®, with that searchengine. The search engine can then use those values to optimise searchand/or advertisement selection by the search engine.

X-System can also share arousal values associated with a user browsing aspecific website or pages in a website with a website optimisationsystem so that the website optimisation system can use those values tooptimise the website and/or specific pages (content, layout, soundsetc.).

K. Opportunities for Expansion/Enhancement

The main directions of product improvement and expansion are as follows:

-   Identification of emotional responses to music stimulated by    memories or response to lyrics or other aspects of a song or piece    of music rather than biology—developed by filtering out the expected    physiological responses.-   Sensor development and accessories, such as new generations of    miniature Electroencephalography (EEG) brain scanning sensors. One    possible approach is to include sensors (measuring any of the    parameters discussed above, such as pulse, skin conductance etc) in    earbuds or in gloves.-   Advanced music search, navigation and discovery systems.-   Advanced music search, navigation and discovery systems, including    promotion, ordering, selection, and control interfaces.-   Specialist medical applications.-   Analysis of music to determine innate emotional responses; and-   Capture and analysis of sensor data from early adopters to fine-tune    level of arousal.

There are two further strategies for refining analytical functions. Thefirst is through large-scale usage of the system. It is proposed torecruit one hundred volunteers to test the system in five phases. Theirphysiological data during listening, including heart rate and skinconductance readings, will be compared with automatic categorisationdata and the results of manual categorisation, as a means of identifyingstrengths and weaknesses in the automatic analysis process, both in thecapture of data and in the combination of values.

The second strategy for refinement is through machine learning, makinguse of linear regressive and/or neural network approaches. Trainingphases will follow each of the five testing phases. This approach willhave the value of both scrutinising existing values and theircombinations, and building up an evolving resource of learnt informationand procedure. It may not be possible to refine the automatedclassification significantly. If this proves to be the case, machinelearning processes and statistical analysis will be used to generate thenecessary refinement. Additionally, weaknesses in the automaticclassification system can be corrected through gathering and analysingthe actual measurements of the effects of specific tracks on users.Those skilled in the art will appreciate that both artificialintelligence (AI) and heuristic rules-based approaches, and iterativeautomation and testing methodologies, may be employed.

X-system could also be used to create and adjust ‘mood’ in retailenvironments, and/or in online communities, through the playback ofsuitable music. Individuals could be connected via web interfaces togenerate a common response/reading.

Similarly, X-System could be used in the understanding of and thematching of emotional responses to brands—essentially using X-System asa tool by which to diagnose and then shape emotional responses to brandsby associating those brands with exactly the right kind of music for thetarget audience. X-System can be used in judging the response ofdifferent social groups to brand music.

Using polling or similar crowd-sensing techniques, X-System can also beused as a dynamic group entrainment tool in group environments, toselect music which heightens arousal, for example at sports orentertainment events, and to reduce group tension and frustration inpublic environments such as transport, hospitals and governmentbuildings.

L. Benefits of X-System

This technology is anticipated to have broad social, psychological andbiological benefits in the reduction of stress, the treatment ofinsomnia, in optimising concentration and learning, in improvingcreative thought, and in facilitating optimal exercise patterns, whetherfor the general population or to support training regimes for eliteathletes, and enhance event competitiveness.

X-System may be applied in therapeutic approaches to specific medicalconditions. There is a large body of literature that provides evidenceof the efficacy of music medicine and music therapy as complementarysupport in the treatment of conditions such as chronic pain, dementia,Parkinsons disease, depression, post-traumatic stress disorder andaphasia, and in palliative, post-surgical, post-stroke care. Possiblebenefits include reduction of bed rest after surgery, and reduction ofdrug use.

As an example, Jane would like to be able to concentrate better on thetask at hand, so she slips on the wireless sensor wristband, touches the“concentrate” symbol on her iPhone and listens as she gets on with herwork. The system will monitor her state of mind and body and play musicsuitable for maintaining an appropriate level of concentration.

It should be noted that in addition the automatic categorisationalgorithms of X-System have considerable potential market value as a“stand alone”, independent of the sensor technology, capable of offeringan “emotional” navigation capacity for music streaming systems.

The invention may be used beneficially to select and categorise musicaccording to its neuro-physiological effect, including but not limitedto the ordering/sequencing, use, promotion, purchase and sale of musicaccording to its neuro-physiological impact. The invention may also beused beneficially to link such categorisation to other categorisationschemes in common use.

Other potential uses of this system could be for selecting appropriatepieces of music from a database of library music for the soundtrack infilms where a specific mood of the viewer is desired. It could also beused in visual arts, where a specific mood of the viewer is desired.Hence these applications would be visual applications or audiovisualapplications, rather than just audio applications.

Related products and services will be generated from both of these areasto generate market intelligence about future trends in markets, i.e.products and services relating to analysis of music to determine innateemotional response, and capture and analysis of sensor data from earlyadopters to fine-tune level of arousal will be generated to generateintelligence about trends in future markets. Examples may includeservices to the computer game industry to assist in sound trackselection to enhance the emotional experience of interactive gamingtechnology or as an aid to music composers seeking to elicit aparticular response to either the whole of, or part of, a proposedmusical composition.

Notes

It is to be understood that the above-referenced arrangements are onlyillustrative of the application for the principles of the presentinvention. Numerous modifications and alternative arrangements can bedevised without departing from the spirit and scope of the presentinvention. While the present invention has been shown in the drawingsand fully described above with particularity and detail in connectionwith what is presently deemed to be the most practical and preferredexample(s) of the invention, it will be apparent to those of ordinaryskill in the art that numerous modifications can be made withoutdeparting from the principles and concepts of the invention as set forthherein. For example, the mathematical equations given in this text arespecific and non-limiting examples only.

Appendix 1 X-System Technical Outline: Component Overview

Fundamentally, the X-System is comprised of 3 components, two of whichare software, and one which is hardware.

One piece of software (the “Music Analyser”) is used in an offline (notdirectly linked to the real-time operation of the system) mode toanalyse the candidate music files, and to build an estimation of theirexcitement/affect influence.

The second software part is the playback component. This is responsiblefor actually playing the music files, and also for receiving data fromthe sensor hardware, and using it to update its internal model whichdetermines subsequent tracks to play.

Finally, the hardware component consists of a number of sensors whichgather real-time data from the local environment, primarily from theactual user.

DETAILED DESCRIPTIONS Music Analysis

The analysis aspect of the music analysis subsystem has been describedin detail elsewhere, and is not covered here. This section covers onlythe integration aspects. As mentioned, this is expected to operateprimarily in an offline, non-interactive fashion. It will be runperiodically against a batch of music inputs, which will result in a setof values describing certain properties of the track. These values canalso be combined to produce a single ‘excitement’ figure for the track,which is used by the playback system. The benefit of storing thecomponents individually is that as data is gathered and used to tunesystem, excitement values can be recomputed with different coefficientswithout the need to re-analyse the entire track, greatly reducingoverhead.

All outputs of the analysis will be stored in a database, indexed on anumber of parameters, including at least track and artist identifiers,and some form of acoustic signature which is relatively tolerant ofencoding differences or background noise.

These indexes will be used when a user ‘imports’ their music collectionto the system. If any tracks already exist in the database, their valuesdo not need to be recomputed.

The feedback process will be an opt-in system in which users agree toprovide anonymised information about their usage of the system in orderto improve it.

Automated features such as normalised change in arousal, replay/skip ofsuggested tracks, and aggregate sensor data can be used. Explicitfeedback in the form of like/dislike acknowledgements, and occasionalrandomised questionnaires may also be used.

Use of feedback to guide system parameters may be on both a global andper-user basis. Large scale data mining, pattern recognition, machinelearning systems will be used to improve affect/arousal estimation ofmusic.

The analysis component will be operated as an internet accessibleservice, either in conjunction with some music streaming service toprovide the audio, or purely as a control system operating with theusers personal music collection.

Where fast & reliable internet service is available, significantfraction of the processing can be offloaded to the hosted X-systemservice. This allows more intensive processing than on a typicalend-device, and also secures the analyser IP.

Additional Uses

Beyond the primary aim of ‘Arousal Adjustment’—facilitating relaxationor excitement—there are other possible uses for the music analysis. Itcan be used to add an additional dimension to music discovery andnavigation, by observing the effect of a large number of short musicsamples on a user, and then suggesting tracks or artists with similarcharacteristics. If the system has been used by someone for anyreasonable time and has a well-adapted personal model, this initial stepmay be unnecessary. Similarity navigation of “Music like Artist/Album X”may also be possible based on features determined during track analysis.

Playback and Decision

The playback component handles 2 tasks. Controlling the music playback,and operating a real-time arousal analysis/entrainment model, based onsensor input. The component may be responsible for actually playing themusic, or may be a control layer on top of an existing media player suchas iTunes/Windows Media Player, etc. The arousal analysis model will bebased on the X-system INRM model, using the pre-computed values from theMusic Analysis component as a starting point. The user will select adesired outcome, and the sensors will be used to gauge progress towardsthat outcome of each track. Explicit overrides will permit the user tomanually skip a particular track either once, or to permanentlyblacklist it to ensure it will never be chosen again for them. Inaddition to their effect, these overrides will feed the decision model.

The capabilities of the component will be somewhat dependent on theenvironment it is operating in. On relatively low-power devices such asphones and portable music players, it may operate in a less precise,less computationally intensive mode, or if possible, offload someprocessing to a remote service.

For laptop/desktop/tablet applications, a more sophisticated model maybe used. For niche uses, it may operate in conjunction with a visualiseror video playback component to enhance the entrainment effect.

It is likely that many users will wish to use the system from multipledifferent hosts, for example both their phone and laptop. The playerrequires some method of synchronising and sharing model data betweenthese systems. This may be best implemented through (or on top of) someinternet service similar to Apple iCloud or Google gDrive. This wouldalso provide the channel for presenting data to the analysis system formodelling/training.

Additional Uses, Comments

Given enough training, it may be possible to develop a version of theX-System that can operate at some level with no sensor feedback. This islikely to be less effective than a well-instrumented setup, but theremay be sufficient value to the user in avoiding the complications ofsensor purchase, upkeep, and inconvenience of wearing. If this provesimpossible or undesirable, it may be possible to obtain some feedbackthrough sensors without direct user attachment, for example aaccelerometer in the phone carried in their pocket, or GPS in the sameindicating their location.

Sensor Hardware

Currently, the sensing part of the system uses two distinct sensors. Oneis a pulse oximeter, which is used to monitor heart-rate, and the otheris a skin conductance sensor, which measures the electrical conductance(the inverse of resistance) of the skin.

Pulse Oximeter

The pulse oximeter operates on the principle of wavelength-dependentabsorption of light by the (oxy-)haemoglobin in the bloodstream. Bycomparing absorption values at red and infra-red wavelengths, therelative proportion of oxygenated blood can be determined, leading tothe ‘blood oxygen saturation’ (spO2) figure. Tracking this value at arelatively high frequency allows detection of the sudden change whichindicates a pulse due to a heart-beat, and hence, heart-beat rate can bedetermined. Whilst very useful in medical contexts, blood oxygenationdoes not change significantly or at timescales useful to the X-System,and only heart-rate data is collected.

The current system uses a COTS sensor, the Nonin 3150 WristOx2 wirelesspulse oximeter. This device uses a soft rubber fingertip clip to housethe light emitter/detectors, which is typical for the type of sensor.Alternatives exist which use sensors clipping gently to the lobe of theear, as well as other parts of the body. This device uses Bluetooth(with the standard and generic SPP—Serial Port Protocol) for datatransmission.

Future implementations of this sensor are likely to use sensor locationsmore convenient and less intrusive than a fingertip. The reliability andaccuracy of the sensor is strongly improved by using direct transmissionabsorption (that is, directing light through a relatively thin body-partsuch as a finger or ear-lobe), but devices do exist which can operate inreflective mode, allowing them to be placed almost anywhere, althoughareas with high blood vessel density, and relatively close to thesurface of the skin are to be preferred. One good site which fits wellwith the x-system goals would be as part of a watch strap, with thesensor on the inside of the wrist, where the buckle lies on a typicalwatch-strap.

Skin Conductance

Skin Conductance, variously termed EDA (Electro-Dermal activity), GSR(Galvanic Skin Resistance), or just Skin Resistance/Conductance, is ameasure of the ability of the skin to carry electrical current. Forobvious safety reasons, the current must be kept very low, and strictlylimited. Baseline skin conductivity depends on a multitude of factorsspecific to individuals and their local environment, but on shorttimescales, the primary influence is that of sweat. Sweat, essentiallyjust water high in electrolytes, is a good conductor, and its presencelowers the effective resistance of the skin. As an aside, Conductance(measured in Siemens/mhos) is defined as the inverse of resistance (inohms). By convention conductance is used when describing these systems,although conversion to resistances is trivial.

Sweating is influenced by a variety of factors, but we are mostinterested in the relation to the parasympathetic nervous system.Increased arousal is strongly correlated with increased sweating, andhence increased skin conductance. This effect is relatively fast, on theorder of seconds. The areas of the body with the highest density ofsweat glands—the working surfaces of the hands and feet—are the mosteffective pickup locations, but other locations are possible, withvarying results. The wrist and outer forearm have been shown to provideadequate results [ref available]

Measuring skin conductance can be achieved in several ways. The currentsensor uses a simple potential divider with a high-precision resistor asone leg, and 2 skin contacts applied to the user serve as the other leg.The central node is also connected to a buffered ADC for measurement.

Other designs exist, and some prototype work has been done on using aWheatstone Bridge—a particular circuit arrangement which allows highlyprecise differential measurements—to improve accuracy and noiserejection.

An important aspect of this parameter is that the value can vary overseveral orders of magnitude. Dry skin, in a cold, dry environment, canhave conductances in the micro-Siemen (Mega-ohm) range, and extremelysweaty skin can go down to hundreds of milli-Siemen (1-1000 Ohms).Accurate measurement across this wide range presents some significantchallenges in sensor design.

The existing sensor, as mentioned, uses a relatively unsophisticatedpotential divider. This is sampled at around 50 Hz by anAnalogue-to-Digital Converter (ADC) integrated into the sensormicrocontroller (MCU).

The particular MCU used at present is the Texas Instruments MSP430F2774.In addition to the ADC, this device contains an integrated programmablegain amplifier (PGA), which is used to magnify the signal from 1× to16×. This provides an effective increase in precision of 4 bits to theexisting 10-bit ADC. Preceding the amplifier is another integratedOp-Amp which is used in follower (unity-gain) mode, which acts to bufferthe signal, and present a high-impedance load to the voltage divider,ensuring that the reading is not skewed due to significant currentflowing through the sampling subsystem.

The ADC input is sampled at approximately 50 Hz. If the measured valuefalls into one of the two regions near the top and bottom of its fullmeasurement range, the gain of the PGA pre-amp is adjusted to raise ittowards the centre of the measurement range. Immediately following thisadjustment (after a short settling period required by the amplifier)another sample is taken. A hysteresis method is implemented at the edgeof each region to minimise the possibility of ‘flip-flopping’ repeatedlybetween 2 amplifier gain levels and interfering with the timelygathering of values. In addition, the relatively high sampling rate (50Hz) compared to the transmission rate of approximately 2 Hz leavesplenty of room for amplifier adjustments. The high sample-rate readingsare averaged using a simple low-pass (FIR) filter with a cutoff of 10Hz.

Samples which fall into these border regions and result in anamplification change are discarded once this second sample completes.Software semaphores are used in the firmware to ensure the communicationsubsystem cannot access the sample buffer whilst it is in use orcontains unreliable data.

If the reading falls into a buffer region but the pre-amp is already setto the maximum or minimum value possible, the reading is stored andtransmitted, but marked with a flag indicating a potentialsaturation/clipping error.

The MCU is also connected to a wireless radio module, which it uses tocommunicate with a USB base-station. The wireless communications operatein the same unregulated frequency band as WiFi and Bluetooth, at 2.4GHz. They are however of much lower power and data-rate, and aredesigned to co-exist with these other devices nearby.

Higher level radio communications are handled using a slightly modifiedversion of the SimpliciTI proprietary network protocol on the sensordevice and base station. This allows multiple sensors to operate inrange of one another while ensuring that data is received by the correctbase-station. Base stations are implemented using a second MSP430, thistime with a USB interface, and which uses the standard USB-Serialdevice-driver which is supported by practically all host devices andoperating systems. Layered on top of the network protocol is theX-System sensor protocol, which exists mainly to facilitate transmissionof sensor readings, provide debugging output, and allow selectiveenabling/disabling of sensors to save power. The update frequency of thesensors can also be adjusted.

The sensors are battery powered, with in-situ charging possible overUSB. This permits fully wireless operation, and minimises any noise thatcould be present in external power supply lines.

Notes

The above section describes the existing implementations, but there area number of additional features planned, but not yet deployed. Theseinclude both upgrades to the current sensing modalities, and also theincorporation of additional types of sensor.

Upgrades Include:

Heart-rate:

-   -   Reflective IR Pulse Oximeter suitable for wrist-mounted sensing.    -   High frequency plethysmographic sampling for heart waveform &        rhythm analysis, beyond a simple ‘heart-rate’ value.

Skin Conductance:

-   -   Wheatstone Bridge based skin conductance pickup, with discrete        or integrated precision instrumentation amplifiers.    -   More sophisticated digital filtering stage    -   Use of synchronised accelerometer attached to/near the skin        contacts used to mark readings as suspicious due to        contact-movement artifacts.

Additional Modalities Include:

EEG type sensors or ‘caps’ for brainwave activity

Electromyograph muscular tone/trigger rate

Multi-point ECG for high-resolution heart waveform

Breathing depth/rate

Eye-tracking/Gaze/blink analysis

Future sources of data which are not yet viable, but which would benefitthe system include: stress hormone (e.g. Cortisol) plasma concentration,neural triggering rate, regional brain activity.

The primary obstacle to be overcome in the development of sensors isconvenience. If aimed at a mass market, few users will toleratecumbersome cables or obstructions of their hands or senses, incomparison to, for example, a therapeutic or medical market.Consolidation of sensors into a single package such as a wrist-watch orheadphone style appliance would be ideal. Other possibilities includeflexible circuits integrated into clothing or footwear.

A sensor package should be capable of interoperability with as many hostdevices as is feasible. This may include smart-phones, feature-phones,tablets, portable music players, laptops, desktops, home hifi, andin-car audio. The most common interfaces are likely WiFi or Bluetooth,although support varies significantly across the range of hostsdescribed.

Appendix 2 Modelling Human Neuro-Physiological Response

The following papers, which are incorporated by reference, provideinformation on modelling the neuro-physiological response of humans.

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1. A method of therapy on a human subject, the method includinganalysing audio tracks for playback to the human subject according to apreselected desired arousal state of the human subject, the methodcomprising the steps of: (i) accessing a set of stored individual audiotracks operable for selection for playback; (ii) predicting aneuro-physiological response to the individual audio tracks according toa neuro-physiological model of the functioning and response of one ormore of the human lower cortical, limbic and subcortical regions in thebrain to sounds; (iii) receiving the selected desired arousal state ofthe human subject; (iv) selecting audio tracks according to thepredicted neuro-physiological response to the individual music tracks,and according to the selected desired arousal state of the humansubject, and (v) playing the selected audio tracks to the human subject.2. The method of therapy of claim 1, wherein the method is used in thetreatment of one or more of: anxiety, pain, dementia, Parkinson'sdisease, depression, post-traumatic stress disorder, aphasia, stress,insomnia, or in palliative, post-surgical, post-stroke care.
 3. Themethod of therapy of claim 2, wherein the method is used ascomplementary support in the treatment.
 4. The method of therapy ofclaim 1, wherein in step (iv) a sequence of audio tracks is selected,and wherein in step (v) the selected sequence of audio tracks is played.5. The method of therapy of claim 1, wherein the arousal state of thehuman subject is defined by galvanic skin conductance or by heart rate.6. The method of therapy of claim 1, wherein the method iscomputer-implemented.
 7. The method of therapy of claim 1, wherein auser interface is presented to a user, the method further comprising thesteps of: (i) the user choosing from a menu of activities in the userinterface (ii) establishing a target level of arousal and affect thatwill facilitate the chosen activity.
 8. The method of therapy of claim1, further comprising the step of an automated categorization processclassifying music tracks and indexing them according to values expressedin a Musical Effect Matrix M.
 9. The method of therapy of claim 1,further comprising the step of analysing tracks for their universalmusical values of rhythmicity, linear harmonic cost and inharmonicity,as well as valence.
 10. The method of therapy of claim 9, furthercomprising the step of analysing tracks for their universal musicalvalues of turbulence.
 11. The method of therapy of claim 10, whereinvalues of rhythmicity, linear harmonic cost, inharmonicity andturbulence, as well as valence, are automatically determined usingsignal processing techniques.
 12. The method of therapy of claim 11,further comprising the step of combining values of rhythmicity,inharmonicity and turbulence as well as valence, to yield a measure ofexcitement or arousal, and positive or negative emotion, mood andfeeling.
 13. The method of therapy of claim 12, wherein excitement Eequals (10*inharmonicity I*rhythmicity R)+turbulence T+linear harmoniccost LHC.
 14. The method of therapy of claim 1, further comprising amethod of ordering a series of pieces of music in a playlist by matchingthe musical effect of each piece with a temporal series of valuesdescribed by a musical effect vector, derived from a predictive model ofhuman lower cortical, limbic and subcortical neuro-physiologicalfunctioning and response to that music.
 15. The method of therapy ofclaim 1, wherein the model of human neuro-physiological response tosound is refined through machine learning, such as linear regressiveand/or neural network approaches.
 16. The method of therapy of claim 1,the method including using a sensor such that once the sensor isactivated, the human subject's initial level of neuro-physiologicalarousal is measured using the sensor, and a playlist is automaticallyconstructed that first mirrors this level of arousal, then directs thehuman subject towards, and helps to maintain them at, the preselecteddesired arousal state of the human subject.
 17. The method of therapy ofclaim 1, the method including creating a playlist in order to entrain ormaintain arousal and direct state of mind and/or affect.
 18. The methodof therapy of claim 1, including sharing arousal values in a socialnetworking application.
 19. A computer program product embodied on anon-transitory storage medium, the computer program product executableto perform a method of therapy on a human subject, the method includinganalysing audio tracks for playback to the human subject according to apreselected desired arousal state of the human subject, the computerprogram product executable to: (i) access a set of stored individualaudio tracks operable for selection for playback; (ii) predict aneuro-physiological response to the individual audio tracks according toa neuro-physiological model of the functioning and response of one ormore of the human lower cortical, limbic and subcortical regions in thebrain to sounds; (iii) receive the selected desired arousal state of thehuman subject; (iv) select audio tracks according to the predictedneuro-physiological response to the individual music tracks, andaccording to the selected desired arousal state of the human subject,and (v) play the selected audio tracks to the human subject.
 20. Acomputing device, adapted to manipulate the arousal of a human subjectby using a method of therapy on the human subject, the device adapted toanalyse audio tracks for playback to the human subject according to apreselected desired arousal state of the human subject, such that thedevice is configured to: (i) access a set of stored individual audiotracks operable for selection for playback; (ii) predict aneuro-physiological response to the individual audio tracks according toa neuro-physiological model of the functioning and response of one ormore of the human lower cortical, limbic and subcortical regions in thebrain to sounds; (iii) receive the selected desired arousal state of thehuman subject; (iv) select audio tracks according to the predictedneuro-physiological response to the individual music tracks, andaccording to the selected desired arousal state of the human subject,and (v) play the selected audio tracks to the human subject.
 21. Thecomputing device of claim 20, wherein the computing device is asmartphone or a tablet computer.